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Association Between High-Sensitivity C-Reactive Protein and Prognosis of Patients with Acute Cerebral Infarction

PURPOSE: To investigate the association of serum high-sensitivity C-reactive protein (hs-CRP) with the severity of neurological deficits and prognosis in patients with acute cerebral infarction (ACI). PATIENTS AND METHODS: In this retrospective analysis, 119 patients with ACI were recruited from Jan...

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Autores principales: Pu, Yuting, Li, Shuangyang, Wang, Lingxue, Fang, Bangjiang, Bai, Xue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400813/
https://www.ncbi.nlm.nih.gov/pubmed/36035076
http://dx.doi.org/10.2147/NDT.S376440
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author Pu, Yuting
Li, Shuangyang
Wang, Lingxue
Fang, Bangjiang
Bai, Xue
author_facet Pu, Yuting
Li, Shuangyang
Wang, Lingxue
Fang, Bangjiang
Bai, Xue
author_sort Pu, Yuting
collection PubMed
description PURPOSE: To investigate the association of serum high-sensitivity C-reactive protein (hs-CRP) with the severity of neurological deficits and prognosis in patients with acute cerebral infarction (ACI). PATIENTS AND METHODS: In this retrospective analysis, 119 patients with ACI were recruited from January to December 2020. The serum hs-CRP level was measured by a latex-enhanced immunoturbidimetric assay. The severity of neurological deficits and prognosis of ACI patients were assessed using the National Institutes of Health Stroke Scale (NIHSS) and the modified Rankin Scale (mRS). Multivariate logistic analysis was performed and receiver operating characteristic (ROC) curves were plotted to evaluate the value of hs-CRP in predicting the prognosis of ACI. RESULTS: The patients with a more favorable prognosis (mRS score 0–2) had a lower median serum hs-CRP level than those with a worse prognosis (mRS score 3–6) (3.32 IQR: 1.51, 8.04 to 17.93 IQR:16.02, 19.01; P<0.001). After adjusting for potential confounders, multivariable linear regression showed that serum hs-CRP level was independently associated with NIHSS score (Beta = 0.952, P<0.001) and mRS score (Beta=0.878, P<0.001). Multivariate logistic analysis revealed that high hs-CRP level was an independent predictor of the poor prognosis in patients with ACI (adjusted(1) OR = 1.995; 95% CI = 1.499–2.655; adjusted(2) OR = 2.75; 95% CI = 1.015–7.457). ROC curve analysis indicated that the area under the curve for hs-CRP to predict poor prognosis was 0.986. The cutoff value, sensitivity, and specificity were 11.835 mg/L, 95%, and 92.5%, respectively. In terms of ischemic stroke subtypes, the serum hs-CRP level was higher in large-artery atherosclerosis (LAA) patients than in those with small-artery occlusion (SAO) and cardioembolism (CE). In addition, the patients with LAA had higher scores of NIHSS and mRS than those with SAO and CE. CONCLUSION: Serum hs-CRP level is an independent predictor of prognosis, and an efficient index to discriminate patients with ACI, especially for those with LAA.
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spelling pubmed-94008132022-08-25 Association Between High-Sensitivity C-Reactive Protein and Prognosis of Patients with Acute Cerebral Infarction Pu, Yuting Li, Shuangyang Wang, Lingxue Fang, Bangjiang Bai, Xue Neuropsychiatr Dis Treat Original Research PURPOSE: To investigate the association of serum high-sensitivity C-reactive protein (hs-CRP) with the severity of neurological deficits and prognosis in patients with acute cerebral infarction (ACI). PATIENTS AND METHODS: In this retrospective analysis, 119 patients with ACI were recruited from January to December 2020. The serum hs-CRP level was measured by a latex-enhanced immunoturbidimetric assay. The severity of neurological deficits and prognosis of ACI patients were assessed using the National Institutes of Health Stroke Scale (NIHSS) and the modified Rankin Scale (mRS). Multivariate logistic analysis was performed and receiver operating characteristic (ROC) curves were plotted to evaluate the value of hs-CRP in predicting the prognosis of ACI. RESULTS: The patients with a more favorable prognosis (mRS score 0–2) had a lower median serum hs-CRP level than those with a worse prognosis (mRS score 3–6) (3.32 IQR: 1.51, 8.04 to 17.93 IQR:16.02, 19.01; P<0.001). After adjusting for potential confounders, multivariable linear regression showed that serum hs-CRP level was independently associated with NIHSS score (Beta = 0.952, P<0.001) and mRS score (Beta=0.878, P<0.001). Multivariate logistic analysis revealed that high hs-CRP level was an independent predictor of the poor prognosis in patients with ACI (adjusted(1) OR = 1.995; 95% CI = 1.499–2.655; adjusted(2) OR = 2.75; 95% CI = 1.015–7.457). ROC curve analysis indicated that the area under the curve for hs-CRP to predict poor prognosis was 0.986. The cutoff value, sensitivity, and specificity were 11.835 mg/L, 95%, and 92.5%, respectively. In terms of ischemic stroke subtypes, the serum hs-CRP level was higher in large-artery atherosclerosis (LAA) patients than in those with small-artery occlusion (SAO) and cardioembolism (CE). In addition, the patients with LAA had higher scores of NIHSS and mRS than those with SAO and CE. CONCLUSION: Serum hs-CRP level is an independent predictor of prognosis, and an efficient index to discriminate patients with ACI, especially for those with LAA. Dove 2022-08-20 /pmc/articles/PMC9400813/ /pubmed/36035076 http://dx.doi.org/10.2147/NDT.S376440 Text en © 2022 Pu et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Pu, Yuting
Li, Shuangyang
Wang, Lingxue
Fang, Bangjiang
Bai, Xue
Association Between High-Sensitivity C-Reactive Protein and Prognosis of Patients with Acute Cerebral Infarction
title Association Between High-Sensitivity C-Reactive Protein and Prognosis of Patients with Acute Cerebral Infarction
title_full Association Between High-Sensitivity C-Reactive Protein and Prognosis of Patients with Acute Cerebral Infarction
title_fullStr Association Between High-Sensitivity C-Reactive Protein and Prognosis of Patients with Acute Cerebral Infarction
title_full_unstemmed Association Between High-Sensitivity C-Reactive Protein and Prognosis of Patients with Acute Cerebral Infarction
title_short Association Between High-Sensitivity C-Reactive Protein and Prognosis of Patients with Acute Cerebral Infarction
title_sort association between high-sensitivity c-reactive protein and prognosis of patients with acute cerebral infarction
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400813/
https://www.ncbi.nlm.nih.gov/pubmed/36035076
http://dx.doi.org/10.2147/NDT.S376440
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