Small molecules targeting the NADH-binding pocket of VDAC modulate mitochondrial metabolism in hepatocarcinoma cells

Voltage dependent anion channels (VDAC) control the flux of most anionic respiratory substrates, ATP, ADP, and small cations, crossing the outer mitochondrial membrane. VDAC closure contributes to the partial suppression of mitochondrial metabolism that favors the Warburg phenotype of cancer cells....

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Detalles Bibliográficos
Autores principales: Heslop, Kareem A., Burger, Pieter, Kappler, Christiana, Solanki, Ashish K., Gooz, Monika, Peterson, Yuri K., Mills, Catherine, Benton, Thomas, Duncan, Stephen A., Woster, Patrick M., Maldonado, Eduardo N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400819/
https://www.ncbi.nlm.nih.gov/pubmed/35447542
http://dx.doi.org/10.1016/j.biopha.2022.112928

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