Spirooxindol‐1,3‐oxazine Alkaloids: Highly Potent and Selective Antitumor Agents Evolved from Iterative Structure Optimization

Spirooxindole‐1,3‐oxazines are a small and structurally unique class of spirooxindole alkaloids. To date, only four of these compounds have been isolated from natural sources, and their biological properties remained unknown thus far. Dioxyreserpine is a synthetic spirooxindole‐1,3‐oxazine, that can...

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Detalles Bibliográficos
Autores principales: Eichhorst, Annika, Gallhof, Malte, Voss, Alice, Sekora, Anett, Eggers, Leon, Huyen, Le Thi, Junghanss, Christian, Murua Escobar, Hugo, Brasholz, Malte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400852/
https://www.ncbi.nlm.nih.gov/pubmed/35491398
http://dx.doi.org/10.1002/cmdc.202200162

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400852/
https://www.ncbi.nlm.nih.gov/pubmed/35491398
http://dx.doi.org/10.1002/cmdc.202200162

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