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Genetic Survey of Psilocybe Natural Products
Psilocybe magic mushrooms are best known for their main natural product, psilocybin, and its dephosphorylated congener, the psychedelic metabolite psilocin. Beyond tryptamines, the secondary metabolome of these fungi is poorly understood. The genomes of five species (P. azurescens, P. cubensis, P. c...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400892/ https://www.ncbi.nlm.nih.gov/pubmed/35583969 http://dx.doi.org/10.1002/cbic.202200249 |
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author | Dörner, Sebastian Rogge, Kai Fricke, Janis Schäfer, Tim Wurlitzer, Jacob M. Gressler, Markus Pham, Duyen N. K. Manke, David R. Chadeayne, Andrew R. Hoffmeister, Dirk |
author_facet | Dörner, Sebastian Rogge, Kai Fricke, Janis Schäfer, Tim Wurlitzer, Jacob M. Gressler, Markus Pham, Duyen N. K. Manke, David R. Chadeayne, Andrew R. Hoffmeister, Dirk |
author_sort | Dörner, Sebastian |
collection | PubMed |
description | Psilocybe magic mushrooms are best known for their main natural product, psilocybin, and its dephosphorylated congener, the psychedelic metabolite psilocin. Beyond tryptamines, the secondary metabolome of these fungi is poorly understood. The genomes of five species (P. azurescens, P. cubensis, P. cyanescens, P. mexicana, and P. serbica) were browsed to understand more profoundly common and species‐specific metabolic capacities. The genomic analyses revealed a much greater and yet unexplored metabolic diversity than evident from parallel chemical analyses. P. cyanescens and P. mexicana were identified as aeruginascin producers. Lumichrome and verpacamide A were also detected as Psilocybe metabolites. The observations concerning the potential secondary metabolome of this fungal genus support pharmacological and toxicological efforts to find a rational basis for yet elusive phenomena, such as paralytic effects, attributed to consumption of some magic mushrooms. |
format | Online Article Text |
id | pubmed-9400892 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94008922022-08-26 Genetic Survey of Psilocybe Natural Products Dörner, Sebastian Rogge, Kai Fricke, Janis Schäfer, Tim Wurlitzer, Jacob M. Gressler, Markus Pham, Duyen N. K. Manke, David R. Chadeayne, Andrew R. Hoffmeister, Dirk Chembiochem Research Articles Psilocybe magic mushrooms are best known for their main natural product, psilocybin, and its dephosphorylated congener, the psychedelic metabolite psilocin. Beyond tryptamines, the secondary metabolome of these fungi is poorly understood. The genomes of five species (P. azurescens, P. cubensis, P. cyanescens, P. mexicana, and P. serbica) were browsed to understand more profoundly common and species‐specific metabolic capacities. The genomic analyses revealed a much greater and yet unexplored metabolic diversity than evident from parallel chemical analyses. P. cyanescens and P. mexicana were identified as aeruginascin producers. Lumichrome and verpacamide A were also detected as Psilocybe metabolites. The observations concerning the potential secondary metabolome of this fungal genus support pharmacological and toxicological efforts to find a rational basis for yet elusive phenomena, such as paralytic effects, attributed to consumption of some magic mushrooms. John Wiley and Sons Inc. 2022-06-09 2022-07-19 /pmc/articles/PMC9400892/ /pubmed/35583969 http://dx.doi.org/10.1002/cbic.202200249 Text en © 2022 The Authors. ChemBioChem published by Wiley-VCH GmbH https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Research Articles Dörner, Sebastian Rogge, Kai Fricke, Janis Schäfer, Tim Wurlitzer, Jacob M. Gressler, Markus Pham, Duyen N. K. Manke, David R. Chadeayne, Andrew R. Hoffmeister, Dirk Genetic Survey of Psilocybe Natural Products |
title | Genetic Survey of Psilocybe Natural Products |
title_full | Genetic Survey of Psilocybe Natural Products |
title_fullStr | Genetic Survey of Psilocybe Natural Products |
title_full_unstemmed | Genetic Survey of Psilocybe Natural Products |
title_short | Genetic Survey of Psilocybe Natural Products |
title_sort | genetic survey of psilocybe natural products |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400892/ https://www.ncbi.nlm.nih.gov/pubmed/35583969 http://dx.doi.org/10.1002/cbic.202200249 |
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