Regio‐ and Stereoselective Epoxidation and Acidic Epoxide Opening of Antibacterial and Antiplasmodial Chlorotonils Yield Highly Potent Derivatives

The rise of antimicrobial resistance poses a severe threat to public health. The natural product chlorotonil was identified as a new antibiotic targeting multidrug resistant Gram‐positive pathogens and Plasmodium falciparum. Although chlorotonil shows promising activities, the scaffold is highly lip...

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Detalles Bibliográficos
Autores principales: Hofer, Walter, Oueis, Emilia, Fayad, Antoine Abou, Deschner, Felix, Andreas, Anastasia, de Carvalho, Laìs Pessanha, Hüttel, Stephan, Bernecker, Steffen, Pätzold, Linda, Morgenstern, Bernd, Zaburannyi, Nestor, Bischoff, Markus, Stadler, Marc, Held, Jana, Herrmann, Jennifer, Müller, Rolf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400904/
https://www.ncbi.nlm.nih.gov/pubmed/35485800
http://dx.doi.org/10.1002/anie.202202816

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400904/
https://www.ncbi.nlm.nih.gov/pubmed/35485800
http://dx.doi.org/10.1002/anie.202202816

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