Cargando…

Regio‐ and Stereoselective Epoxidation and Acidic Epoxide Opening of Antibacterial and Antiplasmodial Chlorotonils Yield Highly Potent Derivatives

The rise of antimicrobial resistance poses a severe threat to public health. The natural product chlorotonil was identified as a new antibiotic targeting multidrug resistant Gram‐positive pathogens and Plasmodium falciparum. Although chlorotonil shows promising activities, the scaffold is highly lip...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hofer, Walter, Oueis, Emilia, Fayad, Antoine Abou, Deschner, Felix, Andreas, Anastasia, de Carvalho, Laìs Pessanha, Hüttel, Stephan, Bernecker, Steffen, Pätzold, Linda, Morgenstern, Bernd, Zaburannyi, Nestor, Bischoff, Markus, Stadler, Marc, Held, Jana, Herrmann, Jennifer, Müller, Rolf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400904/ https://www.ncbi.nlm.nih.gov/pubmed/35485800 http://dx.doi.org/10.1002/anie.202202816

Ejemplares similares

Regio- and Stereoselective Monoepoxidation of Dienes using Methyltrioxorhenium: Synthesis of Allylic Epoxides
por: De, Saroj Ranjan, et al.
Publicado: (2014)

Chiral diboranes as catalysts for the stereoselective organopolymerization of epoxides
por: Sirin-Sariaslan, Ayla, et al.
Publicado: (2022)

Stereoselective Multicomponent Reactions in the Synthesis or Transformations of Epoxides and Aziridines †
por: da Silva, Allan Ribeiro, et al.
Publicado: (2019)

Regio- and Enantioselective Catalytic Monoepoxidation of Conjugated Dienes: Synthesis of Chiral Allylic cis-Epoxides
por: Jat, Jawahar L., et al.
Publicado: (2015)

Remarkable Effect of [Li(G4)]TFSI Solvate Ionic Liquid (SIL) on the Regio- and Stereoselective Ring Opening of α-Gluco Carbasugar 1,2-Epoxides
por: Di Pietro, Sebastiano, et al.
Publicado: (2019)

On the origin of the stereoselectivity in chiral amide-based ammonium ylide-mediated epoxidations
por: Novacek, Johanna, et al.
Publicado: (2016)

Stereoselective Epoxidation of Triterpenic Allylic Alcohols and Cytotoxicity Evaluation of Synthesized Compounds
por: Krainova, Gulnaz, et al.
Publicado: (2023)

Regio- and stereoselective synthesis of new diaminocyclopentanols
por: Larin, Evgeni A, et al.
Publicado: (2014)

Regio- and stereoselective intermolecular carbolithiation reactions
por: Marsico, G., et al.
Publicado: (2020)

Solvent-Dependent Divergent Functions of Sc(OTf)(3) in Stereoselective Epoxide-Opening Spiroketalizations
por: Sharma, Indrajeet, et al.
Publicado: (2014)

Regioselective and Stereoselective Epoxidation of n-3 and n-6 Fatty Acids by Fungal Peroxygenases
por: González-Benjumea, Alejandro, et al.
Publicado: (2021)

Epoxide resins
por: Potter, W G
Publicado: (1970)

Epoxides and their derivatives
por: Malinovskii, M S
Publicado: (1965)

Catalytic developments in the epoxidation of vegetable oils and the analysis methods of epoxidized products
por: Wai, Phyu Thin, et al.
Publicado: (2019)

Molecular Insight into Stereoselective ADME Characteristics of C20-24 Epimeric Epoxides of Protopanaxadiol by Docking Analysis
por: Guo, Wenna, et al.
Publicado: (2020)

An alginate-confined peroxygenase-CLEA for styrene epoxidation
por: Nintzel, Friederike E. H., et al.
Publicado: (2021)

Hydroxy-epoxide and keto-epoxide derivatives of linoleic acid activate trigeminal neurons
por: Doolen, Suzanne, et al.
Publicado: (2020)

Effects of Individual Circulating FFAs on Plasma and Hepatic FFA Epoxides, Diols, and Epoxide-Diol Ratios as Indices of Soluble Epoxide Hydrolase Activity
por: Oh, Young Taek, et al.
Publicado: (2023)

Regio- and stereoselective carbometallation reactions of N-alkynylamides and sulfonamides
por: Minko, Yury, et al.
Publicado: (2013)

Regio‐ and Stereoselective 1,2‐Carboboration of Ynamides with Aryldichloroboranes
por: You, Cai, et al.
Publicado: (2021)

Drug Repurposing: A Review of Old and New Antibiotics for the Treatment of Malaria: Identifying Antibiotics with a Fast Onset of Antiplasmodial Action
por: Pessanha de Carvalho, Lais, et al.
Publicado: (2021)

Soluble Epoxide Hydrolase in Atherosclerosis
por: Wang, Yi-Xin Jim, et al.
Publicado: (2010)

Deoxygenation of Epoxides with Carbon Monoxide
por: Maulbetsch, Theo, et al.
Publicado: (2020)

An Epoxide Intermediate in Glycosidase Catalysis
por: Sobala, Lukasz F., et al.
Publicado: (2020)

Thermodynamics of the Isomerization of Monoterpene Epoxides
por: Sánchez-Velandia, Julián E., et al.
Publicado: (2021)

Iminologous epoxide ring-closure
por: Tien, Chieh-Hung, et al.
Publicado: (2022)

Epoxide Hydrolases: Multipotential Biocatalysts
por: Bučko, Marek, et al.
Publicado: (2023)

Effect of Epoxide Content on the Vulcanizate Structure of Silica-Filled Epoxidized Natural Rubber (ENR) Compounds
por: Ryu, Gyeongchan, et al.
Publicado: (2021)

Efficient regio- and stereoselective access to novel fluorinated β-aminocyclohexanecarboxylates
por: Kiss, Loránd, et al.
Publicado: (2013)

Alkanethiolate-Capped Palladium Nanoparticles for Regio- and Stereoselective Hydrogenation of Allenes
por: Chen, Ting-An, et al.
Publicado: (2018)

Regio‐ and Stereoselective Thianthrenation of Olefins To Access Versatile Alkenyl Electrophiles
por: Chen, Junting, et al.
Publicado: (2020)

Integrated redox-active reagents for photoinduced regio- and stereoselective fluorocarboborylation
por: Zhang, Weigang, et al.
Publicado: (2020)

Regio- and Stereoselective Electrochemical Alkylation of Morita–Baylis–Hillman Adducts
por: Bertuzzi, Giulio, et al.
Publicado: (2022)

Silylium-Catalyzed Regio- and Stereoselective Carbosilylation of Ynamides with Allylic Trimethylsilanes
por: Yepes, Paz, et al.
Publicado: (2023)

Copper(I)-Catalyzed Regio- and Stereoselective Silaboration of Terminal Allenes
por: Ozawa, Yu, et al.
Publicado: (2023)

A molecular electron density theory study of the mechanism, chemo- and stereoselectivity of the epoxidation reaction of R-carvone with peracetic acid
por: Zeroual, Abdellah, et al.
Publicado: (2019)

Stereoselective Synthesis of Bisfuranoxide (Aurochrome, Auroxanthin) and Monofuranoxide (Equinenone 5′,8′-Epoxide) Carotenoids by Double Horner–Wadsworth–Emmons Reaction
por: Rivas, Aurea, et al.
Publicado: (2022)

Regio- and stereoselective oxidation of unactivated C–H bonds with Rhodococcus rhodochrous
por: O’Reilly, Elaine, et al.
Publicado: (2012)

Olefin‐Directed Palladium‐Catalyzed Regio‐ and Stereoselective Oxidative Arylation of Allenes
por: Zhu, Can, et al.
Publicado: (2015)

Exploiting Substrate Promiscuity of Ectoine Hydroxylase for Regio- and Stereoselective Modification of Homoectoine
por: Czech, Laura, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_32jh6c3h5qr16atjdc08r5t6eh