Photochemical Synthesis of the Bioactive Fragment of Salbutamol and Derivatives in a Self‐Optimizing Flow Chemistry Platform

The implementation of self‐optimizing flow reactors has been mostly limited to model reactions or known synthesis routes. In this work, a self‐optimizing flow photochemistry platform is used to develop an original synthesis of the bioactive fragment of Salbutamol and derivatives. The key photochemic...

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Detalles Bibliográficos
Autores principales: Gérardy, Romaric, Nambiar, Anirudh M. K., Hart, Travis, Mahesh, Prajwal T., Jensen, Klavs F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400967/
https://www.ncbi.nlm.nih.gov/pubmed/35570196
http://dx.doi.org/10.1002/chem.202201385
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author Gérardy, Romaric
Nambiar, Anirudh M. K.
Hart, Travis
Mahesh, Prajwal T.
Jensen, Klavs F.
author_facet Gérardy, Romaric
Nambiar, Anirudh M. K.
Hart, Travis
Mahesh, Prajwal T.
Jensen, Klavs F.
author_sort Gérardy, Romaric
collection PubMed
description The implementation of self‐optimizing flow reactors has been mostly limited to model reactions or known synthesis routes. In this work, a self‐optimizing flow photochemistry platform is used to develop an original synthesis of the bioactive fragment of Salbutamol and derivatives. The key photochemical steps for the construction of the aryl vicinyl amino alcohol moiety consist of a C−C bond forming reaction followed by an unprecedented, high yielding (>80 %), benzylic oxidative cyclization.
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spelling pubmed-94009672022-08-26 Photochemical Synthesis of the Bioactive Fragment of Salbutamol and Derivatives in a Self‐Optimizing Flow Chemistry Platform Gérardy, Romaric Nambiar, Anirudh M. K. Hart, Travis Mahesh, Prajwal T. Jensen, Klavs F. Chemistry Research Articles The implementation of self‐optimizing flow reactors has been mostly limited to model reactions or known synthesis routes. In this work, a self‐optimizing flow photochemistry platform is used to develop an original synthesis of the bioactive fragment of Salbutamol and derivatives. The key photochemical steps for the construction of the aryl vicinyl amino alcohol moiety consist of a C−C bond forming reaction followed by an unprecedented, high yielding (>80 %), benzylic oxidative cyclization. John Wiley and Sons Inc. 2022-06-08 2022-08-01 /pmc/articles/PMC9400967/ /pubmed/35570196 http://dx.doi.org/10.1002/chem.202201385 Text en © 2022 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Research Articles
Gérardy, Romaric
Nambiar, Anirudh M. K.
Hart, Travis
Mahesh, Prajwal T.
Jensen, Klavs F.
Photochemical Synthesis of the Bioactive Fragment of Salbutamol and Derivatives in a Self‐Optimizing Flow Chemistry Platform
title Photochemical Synthesis of the Bioactive Fragment of Salbutamol and Derivatives in a Self‐Optimizing Flow Chemistry Platform
title_full Photochemical Synthesis of the Bioactive Fragment of Salbutamol and Derivatives in a Self‐Optimizing Flow Chemistry Platform
title_fullStr Photochemical Synthesis of the Bioactive Fragment of Salbutamol and Derivatives in a Self‐Optimizing Flow Chemistry Platform
title_full_unstemmed Photochemical Synthesis of the Bioactive Fragment of Salbutamol and Derivatives in a Self‐Optimizing Flow Chemistry Platform
title_short Photochemical Synthesis of the Bioactive Fragment of Salbutamol and Derivatives in a Self‐Optimizing Flow Chemistry Platform
title_sort photochemical synthesis of the bioactive fragment of salbutamol and derivatives in a self‐optimizing flow chemistry platform
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400967/
https://www.ncbi.nlm.nih.gov/pubmed/35570196
http://dx.doi.org/10.1002/chem.202201385
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