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The Dynamic Range of Acidity: Tracking Rules for the Unidirectional Penetration of Cellular Compartments
Labeled ammonium cations with pK (a)∼7.4 accumulate in acidic organelles because they can be neutralized transiently to cross the membrane at cytosolic pH 7.2 but not at their internal pH<5.5. Retention in early endosomes with less acidic internal pH was achieved recently using weaker acids of up...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9400975/ https://www.ncbi.nlm.nih.gov/pubmed/35535626 http://dx.doi.org/10.1002/cbic.202200192 |