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Relevance of Palladium to Radiopharmaceutical Development Considering Enhanced Coordination Properties of TE1PA
The limited use of palladium‐103 and ‐109 radionuclides for molecular radiotherapy is surely due to the lack of appropriate ligands capable of fulfilling all criteria required for application in nuclear medicine. Furthermore, the thermodynamic properties of these complexes in solution remain difficu...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9401000/ https://www.ncbi.nlm.nih.gov/pubmed/35560962 http://dx.doi.org/10.1002/chem.202200942 |
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author | Pineau, Julie Lima, Luís M. P. Platas‐Iglesias, Carlos Zeevaart, Jan Rijn Driver, Cathryn H. S. Le Bris, Nathalie Tripier, Raphaël |
author_facet | Pineau, Julie Lima, Luís M. P. Platas‐Iglesias, Carlos Zeevaart, Jan Rijn Driver, Cathryn H. S. Le Bris, Nathalie Tripier, Raphaël |
author_sort | Pineau, Julie |
collection | PubMed |
description | The limited use of palladium‐103 and ‐109 radionuclides for molecular radiotherapy is surely due to the lack of appropriate ligands capable of fulfilling all criteria required for application in nuclear medicine. Furthermore, the thermodynamic properties of these complexes in solution remain difficult to establish. The challenge is compounded when considering that radiolabeling of compounds for translation to clinical trials requires fast complexation. Thus, the coordination of Pd(II) and (103/109)Pd‐nuclides is a huge challenge in terms of molecular design and physicochemical characterization. Herein, we report a comprehensive study highlighting TE1PA, a monopicolinate cyclam – already established in nuclear imaging with (64)Cu‐PET (positron emission tomography) imaging tracers – as a highly relevant chelator for natural Pd and subsequently (109)Pd‐nuclide. The structural, thermodynamic, kinetic and radiolabeling studies of Pd(II) with TE1PA, as well as the comparison of this complex with three structurally related derivatives, support palladium‐TE1PA radiopharmaceuticals as leading candidates for targeted nuclear medicine. |
format | Online Article Text |
id | pubmed-9401000 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94010002022-08-26 Relevance of Palladium to Radiopharmaceutical Development Considering Enhanced Coordination Properties of TE1PA Pineau, Julie Lima, Luís M. P. Platas‐Iglesias, Carlos Zeevaart, Jan Rijn Driver, Cathryn H. S. Le Bris, Nathalie Tripier, Raphaël Chemistry Research Articles The limited use of palladium‐103 and ‐109 radionuclides for molecular radiotherapy is surely due to the lack of appropriate ligands capable of fulfilling all criteria required for application in nuclear medicine. Furthermore, the thermodynamic properties of these complexes in solution remain difficult to establish. The challenge is compounded when considering that radiolabeling of compounds for translation to clinical trials requires fast complexation. Thus, the coordination of Pd(II) and (103/109)Pd‐nuclides is a huge challenge in terms of molecular design and physicochemical characterization. Herein, we report a comprehensive study highlighting TE1PA, a monopicolinate cyclam – already established in nuclear imaging with (64)Cu‐PET (positron emission tomography) imaging tracers – as a highly relevant chelator for natural Pd and subsequently (109)Pd‐nuclide. The structural, thermodynamic, kinetic and radiolabeling studies of Pd(II) with TE1PA, as well as the comparison of this complex with three structurally related derivatives, support palladium‐TE1PA radiopharmaceuticals as leading candidates for targeted nuclear medicine. John Wiley and Sons Inc. 2022-06-10 2022-07-20 /pmc/articles/PMC9401000/ /pubmed/35560962 http://dx.doi.org/10.1002/chem.202200942 Text en © 2022 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Research Articles Pineau, Julie Lima, Luís M. P. Platas‐Iglesias, Carlos Zeevaart, Jan Rijn Driver, Cathryn H. S. Le Bris, Nathalie Tripier, Raphaël Relevance of Palladium to Radiopharmaceutical Development Considering Enhanced Coordination Properties of TE1PA |
title | Relevance of Palladium to Radiopharmaceutical Development Considering Enhanced Coordination Properties of TE1PA |
title_full | Relevance of Palladium to Radiopharmaceutical Development Considering Enhanced Coordination Properties of TE1PA |
title_fullStr | Relevance of Palladium to Radiopharmaceutical Development Considering Enhanced Coordination Properties of TE1PA |
title_full_unstemmed | Relevance of Palladium to Radiopharmaceutical Development Considering Enhanced Coordination Properties of TE1PA |
title_short | Relevance of Palladium to Radiopharmaceutical Development Considering Enhanced Coordination Properties of TE1PA |
title_sort | relevance of palladium to radiopharmaceutical development considering enhanced coordination properties of te1pa |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9401000/ https://www.ncbi.nlm.nih.gov/pubmed/35560962 http://dx.doi.org/10.1002/chem.202200942 |
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