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Automation and Microfluidics for the Efficient, Fast, and Focused Reaction Development of Asymmetric Hydrogenation Catalysis
Automation and microfluidic tools potentially enable efficient, fast, and focused reaction development of complex chemistries, while minimizing resource‐ and material consumption. The introduction of automation‐assisted workflows will contribute to the more sustainable development and scale‐up of ne...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9401021/ https://www.ncbi.nlm.nih.gov/pubmed/35470567 http://dx.doi.org/10.1002/cssc.202200333 |
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author | van Putten, Robbert Eyke, Natalie S. Baumgartner, Lorenz M. Schultz, Victor L. Filonenko, Georgy A. Jensen, Klavs F. Pidko, Evgeny A. |
author_facet | van Putten, Robbert Eyke, Natalie S. Baumgartner, Lorenz M. Schultz, Victor L. Filonenko, Georgy A. Jensen, Klavs F. Pidko, Evgeny A. |
author_sort | van Putten, Robbert |
collection | PubMed |
description | Automation and microfluidic tools potentially enable efficient, fast, and focused reaction development of complex chemistries, while minimizing resource‐ and material consumption. The introduction of automation‐assisted workflows will contribute to the more sustainable development and scale‐up of new and improved catalytic technologies. Herein, the application of automation and microfluidics to the development of a complex asymmetric hydrogenation reaction is described. Screening and optimization experiments were performed using an automated microfluidic platform, which enabled a drastic reduction in the material consumption compared to conventional laboratory practices. A suitable catalytic system was identified from a library of Ru(II)‐diamino precatalysts. In situ precatalyst activation was studied with (1)H/(31)P nuclear magnetic resonance (NMR), and the reaction was scaled up to multigram quantities in a batch autoclave. These reactions were monitored using an automated liquid‐phase sampling system. Ultimately, in less than a week of total experimental time, multigram quantities of the target enantiopure alcohol product were provided by this automation‐assisted approach. |
format | Online Article Text |
id | pubmed-9401021 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94010212022-08-26 Automation and Microfluidics for the Efficient, Fast, and Focused Reaction Development of Asymmetric Hydrogenation Catalysis van Putten, Robbert Eyke, Natalie S. Baumgartner, Lorenz M. Schultz, Victor L. Filonenko, Georgy A. Jensen, Klavs F. Pidko, Evgeny A. ChemSusChem Research Articles Automation and microfluidic tools potentially enable efficient, fast, and focused reaction development of complex chemistries, while minimizing resource‐ and material consumption. The introduction of automation‐assisted workflows will contribute to the more sustainable development and scale‐up of new and improved catalytic technologies. Herein, the application of automation and microfluidics to the development of a complex asymmetric hydrogenation reaction is described. Screening and optimization experiments were performed using an automated microfluidic platform, which enabled a drastic reduction in the material consumption compared to conventional laboratory practices. A suitable catalytic system was identified from a library of Ru(II)‐diamino precatalysts. In situ precatalyst activation was studied with (1)H/(31)P nuclear magnetic resonance (NMR), and the reaction was scaled up to multigram quantities in a batch autoclave. These reactions were monitored using an automated liquid‐phase sampling system. Ultimately, in less than a week of total experimental time, multigram quantities of the target enantiopure alcohol product were provided by this automation‐assisted approach. John Wiley and Sons Inc. 2022-06-03 2022-07-21 /pmc/articles/PMC9401021/ /pubmed/35470567 http://dx.doi.org/10.1002/cssc.202200333 Text en © 2022 The Authors. ChemSusChem published by Wiley-VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles van Putten, Robbert Eyke, Natalie S. Baumgartner, Lorenz M. Schultz, Victor L. Filonenko, Georgy A. Jensen, Klavs F. Pidko, Evgeny A. Automation and Microfluidics for the Efficient, Fast, and Focused Reaction Development of Asymmetric Hydrogenation Catalysis |
title | Automation and Microfluidics for the Efficient, Fast, and Focused Reaction Development of Asymmetric Hydrogenation Catalysis |
title_full | Automation and Microfluidics for the Efficient, Fast, and Focused Reaction Development of Asymmetric Hydrogenation Catalysis |
title_fullStr | Automation and Microfluidics for the Efficient, Fast, and Focused Reaction Development of Asymmetric Hydrogenation Catalysis |
title_full_unstemmed | Automation and Microfluidics for the Efficient, Fast, and Focused Reaction Development of Asymmetric Hydrogenation Catalysis |
title_short | Automation and Microfluidics for the Efficient, Fast, and Focused Reaction Development of Asymmetric Hydrogenation Catalysis |
title_sort | automation and microfluidics for the efficient, fast, and focused reaction development of asymmetric hydrogenation catalysis |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9401021/ https://www.ncbi.nlm.nih.gov/pubmed/35470567 http://dx.doi.org/10.1002/cssc.202200333 |
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