An endo‐Directing‐Group Strategy Unlocks Enantioselective (3+1+2) Carbonylative Cycloadditions of Aminocyclopropanes

An endo‐directing group strategy enables enantioselective (3+1+2) cycloadditions that are triggered by carbonylative C−C bond activation of cyclopropanes. These processes are rare examples of cycloadditions where C−C bond oxidative addition is enantiodetermining, and the first where this is achieved...

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Detalles Bibliográficos
Autores principales: Sokolova, Olga O., Bower, John F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9401022/
https://www.ncbi.nlm.nih.gov/pubmed/35611866
http://dx.doi.org/10.1002/anie.202205007
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author Sokolova, Olga O.
Bower, John F.
author_facet Sokolova, Olga O.
Bower, John F.
author_sort Sokolova, Olga O.
collection PubMed
description An endo‐directing group strategy enables enantioselective (3+1+2) cycloadditions that are triggered by carbonylative C−C bond activation of cyclopropanes. These processes are rare examples of cycloadditions where C−C bond oxidative addition is enantiodetermining, and the first where this is achieved within the context of a multicomponent (higher order) reaction design.
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spelling pubmed-94010222022-08-26 An endo‐Directing‐Group Strategy Unlocks Enantioselective (3+1+2) Carbonylative Cycloadditions of Aminocyclopropanes Sokolova, Olga O. Bower, John F. Angew Chem Int Ed Engl Communications An endo‐directing group strategy enables enantioselective (3+1+2) cycloadditions that are triggered by carbonylative C−C bond activation of cyclopropanes. These processes are rare examples of cycloadditions where C−C bond oxidative addition is enantiodetermining, and the first where this is achieved within the context of a multicomponent (higher order) reaction design. John Wiley and Sons Inc. 2022-06-24 2022-08-08 /pmc/articles/PMC9401022/ /pubmed/35611866 http://dx.doi.org/10.1002/anie.202205007 Text en © 2022 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Communications
Sokolova, Olga O.
Bower, John F.
An endo‐Directing‐Group Strategy Unlocks Enantioselective (3+1+2) Carbonylative Cycloadditions of Aminocyclopropanes
title An endo‐Directing‐Group Strategy Unlocks Enantioselective (3+1+2) Carbonylative Cycloadditions of Aminocyclopropanes
title_full An endo‐Directing‐Group Strategy Unlocks Enantioselective (3+1+2) Carbonylative Cycloadditions of Aminocyclopropanes
title_fullStr An endo‐Directing‐Group Strategy Unlocks Enantioselective (3+1+2) Carbonylative Cycloadditions of Aminocyclopropanes
title_full_unstemmed An endo‐Directing‐Group Strategy Unlocks Enantioselective (3+1+2) Carbonylative Cycloadditions of Aminocyclopropanes
title_short An endo‐Directing‐Group Strategy Unlocks Enantioselective (3+1+2) Carbonylative Cycloadditions of Aminocyclopropanes
title_sort endo‐directing‐group strategy unlocks enantioselective (3+1+2) carbonylative cycloadditions of aminocyclopropanes
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9401022/
https://www.ncbi.nlm.nih.gov/pubmed/35611866
http://dx.doi.org/10.1002/anie.202205007
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