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Derivatives of Natural Organocatalytic Cofactors and Artificial Organocatalytic Cofactors as Catalysts in Enzymes

Catalytically active non‐metal cofactors in enzymes carry out a variety of different reactions. The efforts to develop derivatives of naturally occurring cofactors such as flavins or pyridoxal phosphate and the advances to design new, non‐natural cofactors are reviewed here. We report the status quo...

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Detalles Bibliográficos
Autores principales: Lechner, Horst, Oberdorfer, Gustav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9401024/
https://www.ncbi.nlm.nih.gov/pubmed/35302276
http://dx.doi.org/10.1002/cbic.202100599
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author Lechner, Horst
Oberdorfer, Gustav
author_facet Lechner, Horst
Oberdorfer, Gustav
author_sort Lechner, Horst
collection PubMed
description Catalytically active non‐metal cofactors in enzymes carry out a variety of different reactions. The efforts to develop derivatives of naturally occurring cofactors such as flavins or pyridoxal phosphate and the advances to design new, non‐natural cofactors are reviewed here. We report the status quo for enzymes harboring organocatalysts as derivatives of natural cofactors or as artificial ones and their application in the asymmetric synthesis of various compounds.
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spelling pubmed-94010242022-08-26 Derivatives of Natural Organocatalytic Cofactors and Artificial Organocatalytic Cofactors as Catalysts in Enzymes Lechner, Horst Oberdorfer, Gustav Chembiochem Reviews Catalytically active non‐metal cofactors in enzymes carry out a variety of different reactions. The efforts to develop derivatives of naturally occurring cofactors such as flavins or pyridoxal phosphate and the advances to design new, non‐natural cofactors are reviewed here. We report the status quo for enzymes harboring organocatalysts as derivatives of natural cofactors or as artificial ones and their application in the asymmetric synthesis of various compounds. John Wiley and Sons Inc. 2022-04-01 2022-07-05 /pmc/articles/PMC9401024/ /pubmed/35302276 http://dx.doi.org/10.1002/cbic.202100599 Text en © 2022 The Authors. ChemBioChem published by Wiley-VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Lechner, Horst
Oberdorfer, Gustav
Derivatives of Natural Organocatalytic Cofactors and Artificial Organocatalytic Cofactors as Catalysts in Enzymes
title Derivatives of Natural Organocatalytic Cofactors and Artificial Organocatalytic Cofactors as Catalysts in Enzymes
title_full Derivatives of Natural Organocatalytic Cofactors and Artificial Organocatalytic Cofactors as Catalysts in Enzymes
title_fullStr Derivatives of Natural Organocatalytic Cofactors and Artificial Organocatalytic Cofactors as Catalysts in Enzymes
title_full_unstemmed Derivatives of Natural Organocatalytic Cofactors and Artificial Organocatalytic Cofactors as Catalysts in Enzymes
title_short Derivatives of Natural Organocatalytic Cofactors and Artificial Organocatalytic Cofactors as Catalysts in Enzymes
title_sort derivatives of natural organocatalytic cofactors and artificial organocatalytic cofactors as catalysts in enzymes
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9401024/
https://www.ncbi.nlm.nih.gov/pubmed/35302276
http://dx.doi.org/10.1002/cbic.202100599
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