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Derivatives of Natural Organocatalytic Cofactors and Artificial Organocatalytic Cofactors as Catalysts in Enzymes
Catalytically active non‐metal cofactors in enzymes carry out a variety of different reactions. The efforts to develop derivatives of naturally occurring cofactors such as flavins or pyridoxal phosphate and the advances to design new, non‐natural cofactors are reviewed here. We report the status quo...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9401024/ https://www.ncbi.nlm.nih.gov/pubmed/35302276 http://dx.doi.org/10.1002/cbic.202100599 |
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author | Lechner, Horst Oberdorfer, Gustav |
author_facet | Lechner, Horst Oberdorfer, Gustav |
author_sort | Lechner, Horst |
collection | PubMed |
description | Catalytically active non‐metal cofactors in enzymes carry out a variety of different reactions. The efforts to develop derivatives of naturally occurring cofactors such as flavins or pyridoxal phosphate and the advances to design new, non‐natural cofactors are reviewed here. We report the status quo for enzymes harboring organocatalysts as derivatives of natural cofactors or as artificial ones and their application in the asymmetric synthesis of various compounds. |
format | Online Article Text |
id | pubmed-9401024 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94010242022-08-26 Derivatives of Natural Organocatalytic Cofactors and Artificial Organocatalytic Cofactors as Catalysts in Enzymes Lechner, Horst Oberdorfer, Gustav Chembiochem Reviews Catalytically active non‐metal cofactors in enzymes carry out a variety of different reactions. The efforts to develop derivatives of naturally occurring cofactors such as flavins or pyridoxal phosphate and the advances to design new, non‐natural cofactors are reviewed here. We report the status quo for enzymes harboring organocatalysts as derivatives of natural cofactors or as artificial ones and their application in the asymmetric synthesis of various compounds. John Wiley and Sons Inc. 2022-04-01 2022-07-05 /pmc/articles/PMC9401024/ /pubmed/35302276 http://dx.doi.org/10.1002/cbic.202100599 Text en © 2022 The Authors. ChemBioChem published by Wiley-VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Reviews Lechner, Horst Oberdorfer, Gustav Derivatives of Natural Organocatalytic Cofactors and Artificial Organocatalytic Cofactors as Catalysts in Enzymes |
title | Derivatives of Natural Organocatalytic Cofactors and Artificial Organocatalytic Cofactors as Catalysts in Enzymes |
title_full | Derivatives of Natural Organocatalytic Cofactors and Artificial Organocatalytic Cofactors as Catalysts in Enzymes |
title_fullStr | Derivatives of Natural Organocatalytic Cofactors and Artificial Organocatalytic Cofactors as Catalysts in Enzymes |
title_full_unstemmed | Derivatives of Natural Organocatalytic Cofactors and Artificial Organocatalytic Cofactors as Catalysts in Enzymes |
title_short | Derivatives of Natural Organocatalytic Cofactors and Artificial Organocatalytic Cofactors as Catalysts in Enzymes |
title_sort | derivatives of natural organocatalytic cofactors and artificial organocatalytic cofactors as catalysts in enzymes |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9401024/ https://www.ncbi.nlm.nih.gov/pubmed/35302276 http://dx.doi.org/10.1002/cbic.202100599 |
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