Commonly Used Alkylating Agents Limit Persulfide Detection by Converting Protein Persulfides into Thioethers

Protein persulfides (R‐S‐SH) have emerged as a common post‐translational modification. Detection and quantitation of protein persulfides requires trapping with alkylating agents. Here we show that alkylating agents differ dramatically in their ability to conserve the persulfide's sulfur–sulfur...

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Detalles Bibliográficos
Autores principales: Schilling, Danny, Barayeu, Uladzimir, Steimbach, Raphael R., Talwar, Deepti, Miller, Aubry K., Dick, Tobias P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9401046/
https://www.ncbi.nlm.nih.gov/pubmed/35506673
http://dx.doi.org/10.1002/anie.202203684

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9401046/
https://www.ncbi.nlm.nih.gov/pubmed/35506673
http://dx.doi.org/10.1002/anie.202203684

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