Design and Synthesis of 6‐O‐Phosphorylated Heparan Sulfate Oligosaccharides to Inhibit Amyloid β Aggregation

Dysregulation of amyloidogenic proteins and their abnormal processing and deposition in tissues cause systemic and localized amyloidosis. Formation of amyloid β (Aβ) fibrils that deposit as amyloid plaques in Alzheimer's disease (AD) brains is an earliest pathological hallmark. The polysulfated...

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Detalles Bibliográficos
Autores principales: Uchimura, Kenji, Nishitsuji, Kazuchika, Chiu, Li‐Ting, Ohgita, Takashi, Saito, Hiroyuki, Allain, Fabrice, Gannedi, Veeranjaneyulu, Wong, Chi‐Huey, Hung, Shang‐Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9401075/
https://www.ncbi.nlm.nih.gov/pubmed/35585797
http://dx.doi.org/10.1002/cbic.202200191

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9401075/
https://www.ncbi.nlm.nih.gov/pubmed/35585797
http://dx.doi.org/10.1002/cbic.202200191

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