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Does a single exposure to social defeat render rats more vulnerable to chemically induced colitis than brief inescapable foot-shocks?

All mammals are to different degrees exposed to stressors being physical or social, which may affect health and well-being. Stressful and traumatic situations have direct effects on immune responses that may alter susceptibility to developing somatic illnesses. In animal research, different types of...

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Autores principales: Milde, Anne Marita, Rød, Anne Marie Kinn, Brekke, Silvia, Gjøen, Hedda, Mesfin, Ghenet, Murison, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9401109/
https://www.ncbi.nlm.nih.gov/pubmed/36001557
http://dx.doi.org/10.1371/journal.pone.0263802
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author Milde, Anne Marita
Rød, Anne Marie Kinn
Brekke, Silvia
Gjøen, Hedda
Mesfin, Ghenet
Murison, Robert
author_facet Milde, Anne Marita
Rød, Anne Marie Kinn
Brekke, Silvia
Gjøen, Hedda
Mesfin, Ghenet
Murison, Robert
author_sort Milde, Anne Marita
collection PubMed
description All mammals are to different degrees exposed to stressors being physical or social, which may affect health and well-being. Stressful and traumatic situations have direct effects on immune responses that may alter susceptibility to developing somatic illnesses. In animal research, different types of stressors have been investigated in studying the effect on bowel disorders, some stressors being more or less of environmental origin. We aimed, therefore, to explore whether a more natural stressor would differ from a stressor of more unnatural characteristics on dextran sulphate sodium (DSS) induced colitis in adult rats. Specifically, whether social stress within a single social defeat (SD) paradigm would be a more potent stressor than brief inescapable foot-shocks (IFS) in causing elevated faecal granulocyte marker protein (GMP), and crypt- and inflammation scores in colonic tissue. Three groups of male Wistar rats were used; socially defeated rats; inescapable foot-shock rats; and comparison rats. Main findings showed no difference between the groups on GMP levels. However, there was a significant difference on inflammation and crypt scores for the distal part of colon, detected through histology, where socially defeated rats were more susceptible. A single SD seems to be more adverse than inescapable foot-shock on DSS induced colitis, but further studies are recommended to validate a broader range of different outcomes comparing two such different rodent stress models.
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spelling pubmed-94011092022-08-25 Does a single exposure to social defeat render rats more vulnerable to chemically induced colitis than brief inescapable foot-shocks? Milde, Anne Marita Rød, Anne Marie Kinn Brekke, Silvia Gjøen, Hedda Mesfin, Ghenet Murison, Robert PLoS One Research Article All mammals are to different degrees exposed to stressors being physical or social, which may affect health and well-being. Stressful and traumatic situations have direct effects on immune responses that may alter susceptibility to developing somatic illnesses. In animal research, different types of stressors have been investigated in studying the effect on bowel disorders, some stressors being more or less of environmental origin. We aimed, therefore, to explore whether a more natural stressor would differ from a stressor of more unnatural characteristics on dextran sulphate sodium (DSS) induced colitis in adult rats. Specifically, whether social stress within a single social defeat (SD) paradigm would be a more potent stressor than brief inescapable foot-shocks (IFS) in causing elevated faecal granulocyte marker protein (GMP), and crypt- and inflammation scores in colonic tissue. Three groups of male Wistar rats were used; socially defeated rats; inescapable foot-shock rats; and comparison rats. Main findings showed no difference between the groups on GMP levels. However, there was a significant difference on inflammation and crypt scores for the distal part of colon, detected through histology, where socially defeated rats were more susceptible. A single SD seems to be more adverse than inescapable foot-shock on DSS induced colitis, but further studies are recommended to validate a broader range of different outcomes comparing two such different rodent stress models. Public Library of Science 2022-08-24 /pmc/articles/PMC9401109/ /pubmed/36001557 http://dx.doi.org/10.1371/journal.pone.0263802 Text en © 2022 Milde et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Milde, Anne Marita
Rød, Anne Marie Kinn
Brekke, Silvia
Gjøen, Hedda
Mesfin, Ghenet
Murison, Robert
Does a single exposure to social defeat render rats more vulnerable to chemically induced colitis than brief inescapable foot-shocks?
title Does a single exposure to social defeat render rats more vulnerable to chemically induced colitis than brief inescapable foot-shocks?
title_full Does a single exposure to social defeat render rats more vulnerable to chemically induced colitis than brief inescapable foot-shocks?
title_fullStr Does a single exposure to social defeat render rats more vulnerable to chemically induced colitis than brief inescapable foot-shocks?
title_full_unstemmed Does a single exposure to social defeat render rats more vulnerable to chemically induced colitis than brief inescapable foot-shocks?
title_short Does a single exposure to social defeat render rats more vulnerable to chemically induced colitis than brief inescapable foot-shocks?
title_sort does a single exposure to social defeat render rats more vulnerable to chemically induced colitis than brief inescapable foot-shocks?
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9401109/
https://www.ncbi.nlm.nih.gov/pubmed/36001557
http://dx.doi.org/10.1371/journal.pone.0263802
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