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A Metabologenomic approach reveals alterations in the gut microbiota of a mouse model of Alzheimer’s disease

The key role played by host-microbiota interactions on human health, disease onset and progression, and on host response to treatments has increasingly emerged in the latest decades. Indeed, dysbiosis has been associated to several human diseases such as obesity, diabetes, cancer and also neurodegen...

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Autores principales: Favero, Francesco, Barberis, Elettra, Gagliardi, Mara, Espinoza, Stefano, Contu, Liliana, Gustincich, Stefano, Boccafoschi, Francesca, Borsotti, Chiara, Lim, Dmitry, Rubino, Vito, Mignone, Flavio, Pasolli, Edoardo, Manfredi, Marcello, Zucchelli, Silvia, Corà, Davide, Corazzari, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9401139/
https://www.ncbi.nlm.nih.gov/pubmed/36001607
http://dx.doi.org/10.1371/journal.pone.0273036
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author Favero, Francesco
Barberis, Elettra
Gagliardi, Mara
Espinoza, Stefano
Contu, Liliana
Gustincich, Stefano
Boccafoschi, Francesca
Borsotti, Chiara
Lim, Dmitry
Rubino, Vito
Mignone, Flavio
Pasolli, Edoardo
Manfredi, Marcello
Zucchelli, Silvia
Corà, Davide
Corazzari, Marco
author_facet Favero, Francesco
Barberis, Elettra
Gagliardi, Mara
Espinoza, Stefano
Contu, Liliana
Gustincich, Stefano
Boccafoschi, Francesca
Borsotti, Chiara
Lim, Dmitry
Rubino, Vito
Mignone, Flavio
Pasolli, Edoardo
Manfredi, Marcello
Zucchelli, Silvia
Corà, Davide
Corazzari, Marco
author_sort Favero, Francesco
collection PubMed
description The key role played by host-microbiota interactions on human health, disease onset and progression, and on host response to treatments has increasingly emerged in the latest decades. Indeed, dysbiosis has been associated to several human diseases such as obesity, diabetes, cancer and also neurodegenerative disease, such as Parkinson, Huntington and Alzheimer’s disease (AD), although whether causative, consequence or merely an epiphenomenon is still under investigation. In the present study, we performed a metabologenomic analysis of stool samples from a mouse model of AD, the 3xTgAD. We found a significant change in the microbiota of AD mice compared to WT, with a longitudinal divergence of the F/B ratio, a parameter suggesting a gut dysbiosis. Moreover, AD mice showed a significant decrease of some amino acids, while data integration revealed a dysregulated production of desaminotyrosine (DAT) and dihydro-3-coumaric acid. Collectively, our data show a dysregulated gut microbiota associated to the onset and progression of AD, also indicating that a dysbiosis can occur prior to significant clinical signs, evidenced by early SCFA alterations, compatible with gut inflammation.
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spelling pubmed-94011392022-08-25 A Metabologenomic approach reveals alterations in the gut microbiota of a mouse model of Alzheimer’s disease Favero, Francesco Barberis, Elettra Gagliardi, Mara Espinoza, Stefano Contu, Liliana Gustincich, Stefano Boccafoschi, Francesca Borsotti, Chiara Lim, Dmitry Rubino, Vito Mignone, Flavio Pasolli, Edoardo Manfredi, Marcello Zucchelli, Silvia Corà, Davide Corazzari, Marco PLoS One Research Article The key role played by host-microbiota interactions on human health, disease onset and progression, and on host response to treatments has increasingly emerged in the latest decades. Indeed, dysbiosis has been associated to several human diseases such as obesity, diabetes, cancer and also neurodegenerative disease, such as Parkinson, Huntington and Alzheimer’s disease (AD), although whether causative, consequence or merely an epiphenomenon is still under investigation. In the present study, we performed a metabologenomic analysis of stool samples from a mouse model of AD, the 3xTgAD. We found a significant change in the microbiota of AD mice compared to WT, with a longitudinal divergence of the F/B ratio, a parameter suggesting a gut dysbiosis. Moreover, AD mice showed a significant decrease of some amino acids, while data integration revealed a dysregulated production of desaminotyrosine (DAT) and dihydro-3-coumaric acid. Collectively, our data show a dysregulated gut microbiota associated to the onset and progression of AD, also indicating that a dysbiosis can occur prior to significant clinical signs, evidenced by early SCFA alterations, compatible with gut inflammation. Public Library of Science 2022-08-24 /pmc/articles/PMC9401139/ /pubmed/36001607 http://dx.doi.org/10.1371/journal.pone.0273036 Text en © 2022 Favero et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Favero, Francesco
Barberis, Elettra
Gagliardi, Mara
Espinoza, Stefano
Contu, Liliana
Gustincich, Stefano
Boccafoschi, Francesca
Borsotti, Chiara
Lim, Dmitry
Rubino, Vito
Mignone, Flavio
Pasolli, Edoardo
Manfredi, Marcello
Zucchelli, Silvia
Corà, Davide
Corazzari, Marco
A Metabologenomic approach reveals alterations in the gut microbiota of a mouse model of Alzheimer’s disease
title A Metabologenomic approach reveals alterations in the gut microbiota of a mouse model of Alzheimer’s disease
title_full A Metabologenomic approach reveals alterations in the gut microbiota of a mouse model of Alzheimer’s disease
title_fullStr A Metabologenomic approach reveals alterations in the gut microbiota of a mouse model of Alzheimer’s disease
title_full_unstemmed A Metabologenomic approach reveals alterations in the gut microbiota of a mouse model of Alzheimer’s disease
title_short A Metabologenomic approach reveals alterations in the gut microbiota of a mouse model of Alzheimer’s disease
title_sort metabologenomic approach reveals alterations in the gut microbiota of a mouse model of alzheimer’s disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9401139/
https://www.ncbi.nlm.nih.gov/pubmed/36001607
http://dx.doi.org/10.1371/journal.pone.0273036
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