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Comparative pharmacokinetics of valproic acid among Pakistani and South Korean patients: A population pharmacokinetic study
PURPOSE: The pharmacokinetics of valproic acid have been evaluated in a variety of populations however, the comparison in two different populations was yet to be reported. This study is aimed to compare the pharmacokinetics of valproic acid in Pakistani and South Korean patients. METHOD: The therape...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9401156/ https://www.ncbi.nlm.nih.gov/pubmed/36001534 http://dx.doi.org/10.1371/journal.pone.0272622 |
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author | Usman, Muhammad Shaukat, Qurrat-ul-Ain Khokhar, Muhammad Imran Bilal, Rabiea Khan, Rizwan Rasul Saeed, Hafiz Asad Ali, Mohsin Khan, Humaira Majeed |
author_facet | Usman, Muhammad Shaukat, Qurrat-ul-Ain Khokhar, Muhammad Imran Bilal, Rabiea Khan, Rizwan Rasul Saeed, Hafiz Asad Ali, Mohsin Khan, Humaira Majeed |
author_sort | Usman, Muhammad |
collection | PubMed |
description | PURPOSE: The pharmacokinetics of valproic acid have been evaluated in a variety of populations however, the comparison in two different populations was yet to be reported. This study is aimed to compare the pharmacokinetics of valproic acid in Pakistani and South Korean patients. METHOD: The therapeutic drug monitoring (TDM) data of valproic acid from 92 Pakistani patients with 218 samples was combined with the data of 99 South Korean patients with 335 samples in order to form a pooled dataset of 191 patients with 553 samples. Population pharmacokinetic model was developed on NONMEM® software by using first order conditional estimation method for estimation of pharmacokinetic parameters. The influence of different covariates including ethnicity was evaluated the stepwise covariate modelling. The final model was evaluated for predictive performance and robustness by using goodness of fit plots and bootstrap analysis respectively. RESULTS: The data was better described by one compartment model with first order elimination. The value for clearance (CL) of valproic in pooled data was 0.931 L/h with 43.4% interindividual variability (IIV) while volume of distribution (V(d)) was 16.6 L with 22.3% IIV. In covariate analysis, ethnicity and body weight were significant covariates for CL while body weight was also significant for V(d). CONCLUSION: A significant difference in CL of valproic acid among Pakistani and South Korean patients was observed. The model can be used for the dose tailoring of valproic acid based on ethnicity and body weight of Pakistani and South Korean patients. |
format | Online Article Text |
id | pubmed-9401156 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-94011562022-08-25 Comparative pharmacokinetics of valproic acid among Pakistani and South Korean patients: A population pharmacokinetic study Usman, Muhammad Shaukat, Qurrat-ul-Ain Khokhar, Muhammad Imran Bilal, Rabiea Khan, Rizwan Rasul Saeed, Hafiz Asad Ali, Mohsin Khan, Humaira Majeed PLoS One Research Article PURPOSE: The pharmacokinetics of valproic acid have been evaluated in a variety of populations however, the comparison in two different populations was yet to be reported. This study is aimed to compare the pharmacokinetics of valproic acid in Pakistani and South Korean patients. METHOD: The therapeutic drug monitoring (TDM) data of valproic acid from 92 Pakistani patients with 218 samples was combined with the data of 99 South Korean patients with 335 samples in order to form a pooled dataset of 191 patients with 553 samples. Population pharmacokinetic model was developed on NONMEM® software by using first order conditional estimation method for estimation of pharmacokinetic parameters. The influence of different covariates including ethnicity was evaluated the stepwise covariate modelling. The final model was evaluated for predictive performance and robustness by using goodness of fit plots and bootstrap analysis respectively. RESULTS: The data was better described by one compartment model with first order elimination. The value for clearance (CL) of valproic in pooled data was 0.931 L/h with 43.4% interindividual variability (IIV) while volume of distribution (V(d)) was 16.6 L with 22.3% IIV. In covariate analysis, ethnicity and body weight were significant covariates for CL while body weight was also significant for V(d). CONCLUSION: A significant difference in CL of valproic acid among Pakistani and South Korean patients was observed. The model can be used for the dose tailoring of valproic acid based on ethnicity and body weight of Pakistani and South Korean patients. Public Library of Science 2022-08-24 /pmc/articles/PMC9401156/ /pubmed/36001534 http://dx.doi.org/10.1371/journal.pone.0272622 Text en © 2022 Usman et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Usman, Muhammad Shaukat, Qurrat-ul-Ain Khokhar, Muhammad Imran Bilal, Rabiea Khan, Rizwan Rasul Saeed, Hafiz Asad Ali, Mohsin Khan, Humaira Majeed Comparative pharmacokinetics of valproic acid among Pakistani and South Korean patients: A population pharmacokinetic study |
title | Comparative pharmacokinetics of valproic acid among Pakistani and South Korean patients: A population pharmacokinetic study |
title_full | Comparative pharmacokinetics of valproic acid among Pakistani and South Korean patients: A population pharmacokinetic study |
title_fullStr | Comparative pharmacokinetics of valproic acid among Pakistani and South Korean patients: A population pharmacokinetic study |
title_full_unstemmed | Comparative pharmacokinetics of valproic acid among Pakistani and South Korean patients: A population pharmacokinetic study |
title_short | Comparative pharmacokinetics of valproic acid among Pakistani and South Korean patients: A population pharmacokinetic study |
title_sort | comparative pharmacokinetics of valproic acid among pakistani and south korean patients: a population pharmacokinetic study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9401156/ https://www.ncbi.nlm.nih.gov/pubmed/36001534 http://dx.doi.org/10.1371/journal.pone.0272622 |
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