Integrative Profiling of T790M-Negative EGFR-Mutated NSCLC Reveals Pervasive Lineage Transition and Therapeutic Opportunities

PURPOSE: Despite the established role of EGFR tyrosine kinase inhibitors (TKIs) in EGFR-mutated NSCLC, drug resistance inevitably ensues, with a paucity of treatment options especially in EGFR(T790M)-negative resistance. EXPERIMENTAL DESIGN: We performed whole-exome and transcriptome analysis of 59...

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Detalles Bibliográficos
Autores principales: Chua, Khi Pin, Teng, Yvonne H.F., Tan, Aaron C., Takano, Angela, Alvarez, Jacob J.S., Nahar, Rahul, Rohatgi, Neha, Lai, Gillianne G.Y., Aung, Zaw Win, Yeong, Joe P.S., Lim, Kiat Hon, Naeini, Marjan Mojtabavi, Kassam, Irfahan, Jain, Amit, Tan, Wan Ling, Gogna, Apoorva, Too, Chow Wei, Kanesvaran, Ravindran, Ng, Quan Sing, Ang, Mei Kim, Rajasekaran, Tanujaa, Anantham, Devanand, Phua, Ghee Chee, Tan, Bien Soo, Lee, Yin Yeng, Wang, Lanying, Teo, Audrey S.M., Khng, Alexis Jiaying, Lim, Ming Jie, Suteja, Lisda, Toh, Chee Keong, Lim, Wan-Teck, Iyer, N. Gopalakrishna, Tam, Wai Leong, Tan, Eng-Huat, Zhai, Weiwei, Hillmer, Axel M., Skanderup, Anders J., Tan, Daniel S.W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2021
Materias:
Translational Cancer Mechanisms and Therapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9401458/
https://www.ncbi.nlm.nih.gov/pubmed/34261696
http://dx.doi.org/10.1158/1078-0432.CCR-20-4607

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