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Organoids Derived from Neoadjuvant FOLFIRINOX Patients Recapitulate Therapy Resistance in Pancreatic Ductal Adenocarcinoma

PURPOSE: We investigated whether organoids can be generated from resected tumors of patients who received eight cycles of neoadjuvant FOLFIRINOX chemotherapy before surgery, and evaluated the sensitivity/resistance of these surviving cancer cells to cancer therapy. EXPERIMENTAL DESIGN: We generated...

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Detalles Bibliográficos
Autores principales:	Farshadi, Elham Aida, Chang, Jiang, Sampadi, Bharath, Doukas, Michail, Van 't Land, Freek, van der Sijde, Fleur, Vietsch, Eveline E., Pothof, Joris, Koerkamp, Bas Groot, van Eijck, Casper H.J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2021
Materias:	Translational Cancer Mechanisms and Therapy
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9401459/ https://www.ncbi.nlm.nih.gov/pubmed/34580113 http://dx.doi.org/10.1158/1078-0432.CCR-21-1681

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