Circulating Tumor DNA Analysis Detects FGFR2 Amplification and Concurrent Genomic Alterations Associated with FGFR Inhibitor Efficacy in Advanced Gastric Cancer

PURPOSE: FGFR2 amplification is associated with poor prognosis in advanced gastric cancer and its subclonal heterogeneity has been revealed. Here, we examined whether circulating tumor DNA (ctDNA) was useful for detecting FGFR2 amplification and co-occurring resistance mechanisms in advanced gastric...

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Detalles Bibliográficos
Autores principales: Jogo, Tomoko, Nakamura, Yoshiaki, Shitara, Kohei, Bando, Hideaki, Yasui, Hisateru, Esaki, Taito, Terazawa, Tetsuji, Satoh, Taroh, Shinozaki, Eiji, Nishina, Tomohiro, Sunakawa, Yu, Komatsu, Yoshito, Hara, Hiroki, Oki, Eiji, Matsuhashi, Nobuhisa, Ohta, Takashi, Kato, Takeshi, Ohtsubo, Koushiro, Kawakami, Takeshi, Okano, Naohiro, Yamamoto, Yoshiyuki, Yamada, Takanobu, Tsuji, Akihito, Odegaard, Justin I., Taniguchi, Hiroya, Doi, Toshihiko, Fujii, Satoshi, Yoshino, Takayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2021
Materias:
Translational Cancer Mechanisms and Therapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9401460/
https://www.ncbi.nlm.nih.gov/pubmed/34376535
http://dx.doi.org/10.1158/1078-0432.CCR-21-1414

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