Low-Dose Radiotherapy Reverses Tumor Immune Desertification and Resistance to Immunotherapy

Developing strategies to inflame tumors is critical for increasing response to immunotherapy. Here, we report that low-dose radiotherapy (LDRT) of murine tumors promotes T-cell infiltration and enables responsiveness to combinatorial immunotherapy in an IFN-dependent manner. Treatment efficacy relie...

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Detalles Bibliográficos
Autores principales: Herrera, Fernanda G., Ronet, Catherine, Ochoa de Olza, Maria, Barras, David, Crespo, Isaac, Andreatta, Massimo, Corria-Osorio, Jesus, Spill, Aodrenn, Benedetti, Fabrizio, Genolet, Raphael, Orcurto, Angela, Imbimbo, Martina, Ghisoni, Eleonora, Navarro Rodrigo, Blanca, Berthold, Dominik R., Sarivalasis, Apostolos, Zaman, Khalil, Duran, Rafael, Dromain, Clarisse, Prior, John, Schaefer, Niklaus, Bourhis, Jean, Dimopoulou, Georgia, Tsourti, Zoi, Messemaker, Marius, Smith, Thomas, Warren, Sarah E., Foukas, Periklis, Rusakiewicz, Sylvie, Pittet, Mikaël J., Zimmermann, Stefan, Sempoux, Christine, Dafni, Urania, Harari, Alexandre, Kandalaft, Lana E., Carmona, Santiago J., Dangaj Laniti, Denarda, Irving, Melita, Coukos, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9401506/
https://www.ncbi.nlm.nih.gov/pubmed/34479871
http://dx.doi.org/10.1158/2159-8290.CD-21-0003

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