Pretreatment Tissue TCR Repertoire Evenness Is Associated with Complete Pathologic Response in Patients with NSCLC Receiving Neoadjuvant Chemoimmunotherapy

PURPOSE: Characterization of the T-cell receptor (TCR) repertoire may be a promising source for predictive biomarkers of pathologic response to immunotherapy in locally advanced non–small cell lung cancer (NSCLC). EXPERIMENTAL DESIGN: In this study, next-generation TCR sequencing was performed in pe...

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Detalles Bibliográficos
Autores principales: Casarrubios, Marta, Cruz-Bermúdez, Alberto, Nadal, Ernest, Insa, Amelia, García Campelo, María del Rosario, Lázaro, Martín, Dómine, Manuel, Majem, Margarita, Rodríguez-Abreu, Delvys, Martínez-Martí, Alex, de Castro-Carpeño, Javier, Cobo, Manuel, López-Vivanco, Guillermo, Del Barco, Edel, Bernabé Caro, Reyes, Viñolas, Nuria, Barneto Aranda, Isidoro, Viteri, Santiago, Massuti, Bartomeu, Barquín, Miguel, Laza-Briviesca, Raquel, Sierra-Rodero, Belén, Parra, Edwin R., Sanchez-Espiridion, Beatriz, Rocha, Pedro, Kadara, Humam, Wistuba, Ignacio I., Romero, Atocha, Calvo, Virginia, Provencio, Mariano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2021
Materias:
Precision Medicine and Imaging
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9401519/
https://www.ncbi.nlm.nih.gov/pubmed/34376534
http://dx.doi.org/10.1158/1078-0432.CCR-21-1200

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