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Steroid Ligands, the Forgotten Triggers of Nuclear Receptor Action; Implications for Acquired Resistance to Endocrine Therapy

PURPOSE: There is strong epidemiologic evidence indicating that estrogens may not be the sole steroid drivers of breast cancer. We hypothesize that abundant adrenal androgenic steroid precursors, acting via the androgen receptor (AR), promote an endocrine-resistant breast cancer phenotype. EXPERIMEN...

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Detalles Bibliográficos
Autores principales:	Bleach, Rachel, Madden, Stephen F., Hawley, James, Charmsaz, Sara, Selli, Cigdem, Sheehan, Katherine M., Young, Leonie S., Sims, Andrew H., Souček, Pavel, Hill, Arnold D., McIlroy, Marie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2021
Materias:	Precision Medicine and Imaging
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9401529/ https://www.ncbi.nlm.nih.gov/pubmed/34016642 http://dx.doi.org/10.1158/1078-0432.CCR-20-4135

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