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Rapamycin Pretreatment Rescues the Bone Marrow AML Cell Elimination Capacity of CAR-T Cells

PURPOSE: Ongoing clinical trials show limited efficacy for Chimeric antigen receptor (CAR) T treatment for acute myeloid leukemia (AML). The aim of this study was to identify potential causes of the reported limited efficacy from CAR-T therapies against AML. EXPERIMENTAL DESIGN: We generated CAR-T c...

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Detalles Bibliográficos
Autores principales:	Nian, Zhigang, Zheng, Xiaohu, Dou, Yingchao, Du, Xianghui, Zhou, Li, Fu, Binqing, Sun, Rui, Tian, Zhigang, Wei, Haiming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2021
Materias:	Translational Cancer Mechanisms and Therapy
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9401534/ https://www.ncbi.nlm.nih.gov/pubmed/34233960 http://dx.doi.org/10.1158/1078-0432.CCR-21-0452

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