Prediction of Immunotherapy Response in Melanoma through Combined Modeling of Neoantigen Burden and Immune-Related Resistance Mechanisms

PURPOSE: While immune checkpoint blockade (ICB) has become a pillar of cancer treatment, biomarkers that consistently predict patient response remain elusive due to the complex mechanisms driving immune response to tumors. We hypothesized that a multi-dimensional approach modeling both tumor and imm...

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Detalles Bibliográficos
Autores principales: Abbott, Charles W., Boyle, Sean M., Pyke, Rachel Marty, McDaniel, Lee D., Levy, Eric, Navarro, Fábio C.P., Mellacheruvu, Dattatreya, Zhang, Simo V., Tan, Mengyao, Santiago, Rose, Rusan, Zeid M., Milani, Pamela, Bartha, Gabor, Harris, Jason, McClory, Rena, Snyder, Michael P., Jang, Sekwon, Chen, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2021
Materias:
Precision Medicine and Imaging
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9401549/
https://www.ncbi.nlm.nih.gov/pubmed/34341053
http://dx.doi.org/10.1158/1078-0432.CCR-20-4314

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