Structure‐Based Virtual Screening and in vitro and in vivo Analyses Revealed Potent Methyltransferase G9a Inhibitors as Prospective Anti‐Alzheimer's Agents

G9a is a lysine methyltransferase able to di‐methylate lysine 9 of histone H3, promoting the repression of genes involved in learning and memory. Novel strategies based on synthesizing epigenetic drugs could regulate gene expression through histone post‐translational modifications and effectively tr...

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Detalles Bibliográficos
Autores principales: Bellver‐Sanchis, Aina, Singh Choudhary, Bhanwar, Companys‐Alemany, Júlia, Sukanya, Ávila‐López, Pedro A., Martínez Rodríguez, Antón Leandro, Brea Floriani, Jose Manuel, Malik, Ruchi, Pallàs, Mercè, Pérez, Belén, Griñán‐Ferré, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9401600/
https://www.ncbi.nlm.nih.gov/pubmed/35413149
http://dx.doi.org/10.1002/cmdc.202200002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9401600/
https://www.ncbi.nlm.nih.gov/pubmed/35413149
http://dx.doi.org/10.1002/cmdc.202200002

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