Mechanistic insights into intramembrane proteolysis by E. coli site-2 protease homolog RseP

Site-2 proteases are a conserved family of intramembrane proteases that cleave transmembrane substrates to regulate signal transduction and maintain proteostasis. Here, we elucidated crystal structures of inhibitor-bound forms of bacterial site-2 proteases including Escherichia coli RseP. Structure-...

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Detalles Bibliográficos
Autores principales: Imaizumi, Yuki, Takanuki, Kazunori, Miyake, Takuya, Takemoto, Mizuki, Hirata, Kunio, Hirose, Mika, Oi, Rika, Kobayashi, Tatsuya, Miyoshi, Kenichi, Aruga, Rie, Yokoyama, Tatsuhiko, Katagiri, Shizuka, Matsuura, Hiroaki, Iwasaki, Kenji, Kato, Takayuki, Kaneko, Mika K., Kato, Yukinari, Tajiri, Michiko, Akashi, Satoko, Nureki, Osamu, Hizukuri, Yohei, Akiyama, Yoshinori, Nogi, Terukazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9401612/
https://www.ncbi.nlm.nih.gov/pubmed/36001659
http://dx.doi.org/10.1126/sciadv.abp9011

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