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Bioinspired two-in-one nanotransistor sensor for the simultaneous measurements of electrical and mechanical cellular responses
The excitation-contraction dynamics in cardiac tissue are the most important physiological parameters for assessing developmental state. We demonstrate integrated nanoelectronic sensors capable of simultaneously probing electrical and mechanical cellular responses. The sensor is configured from a th...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9401615/ https://www.ncbi.nlm.nih.gov/pubmed/36001656 http://dx.doi.org/10.1126/sciadv.abn2485 |
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author | Gao, Hongyan Yang, Feiyu Sattari, Kianoosh Du, Xian Fu, Tianda Fu, Shuai Liu, Xiaomeng Lin, Jian Sun, Yubing Yao, Jun |
author_facet | Gao, Hongyan Yang, Feiyu Sattari, Kianoosh Du, Xian Fu, Tianda Fu, Shuai Liu, Xiaomeng Lin, Jian Sun, Yubing Yao, Jun |
author_sort | Gao, Hongyan |
collection | PubMed |
description | The excitation-contraction dynamics in cardiac tissue are the most important physiological parameters for assessing developmental state. We demonstrate integrated nanoelectronic sensors capable of simultaneously probing electrical and mechanical cellular responses. The sensor is configured from a three-dimensional nanotransistor with its conduction channel protruding out of the plane. The structure promotes not only a tight seal with the cell for detecting action potential via field effect but also a close mechanical coupling for detecting cellular force via piezoresistive effect. Arrays of nanotransistors are integrated to realize label-free, submillisecond, and scalable interrogation of correlated cell dynamics, showing advantages in tracking and differentiating cell states in drug studies. The sensor can further decode vector information in cellular motion beyond typical scalar information acquired at the tissue level, hence offering an improved tool for cell mechanics studies. The sensor enables not only improved bioelectronic detections but also reduced invasiveness through the two-in-one converging integration. |
format | Online Article Text |
id | pubmed-9401615 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | American Association for the Advancement of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-94016152022-08-26 Bioinspired two-in-one nanotransistor sensor for the simultaneous measurements of electrical and mechanical cellular responses Gao, Hongyan Yang, Feiyu Sattari, Kianoosh Du, Xian Fu, Tianda Fu, Shuai Liu, Xiaomeng Lin, Jian Sun, Yubing Yao, Jun Sci Adv Physical and Materials Sciences The excitation-contraction dynamics in cardiac tissue are the most important physiological parameters for assessing developmental state. We demonstrate integrated nanoelectronic sensors capable of simultaneously probing electrical and mechanical cellular responses. The sensor is configured from a three-dimensional nanotransistor with its conduction channel protruding out of the plane. The structure promotes not only a tight seal with the cell for detecting action potential via field effect but also a close mechanical coupling for detecting cellular force via piezoresistive effect. Arrays of nanotransistors are integrated to realize label-free, submillisecond, and scalable interrogation of correlated cell dynamics, showing advantages in tracking and differentiating cell states in drug studies. The sensor can further decode vector information in cellular motion beyond typical scalar information acquired at the tissue level, hence offering an improved tool for cell mechanics studies. The sensor enables not only improved bioelectronic detections but also reduced invasiveness through the two-in-one converging integration. American Association for the Advancement of Science 2022-08-24 /pmc/articles/PMC9401615/ /pubmed/36001656 http://dx.doi.org/10.1126/sciadv.abn2485 Text en Copyright © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited. |
spellingShingle | Physical and Materials Sciences Gao, Hongyan Yang, Feiyu Sattari, Kianoosh Du, Xian Fu, Tianda Fu, Shuai Liu, Xiaomeng Lin, Jian Sun, Yubing Yao, Jun Bioinspired two-in-one nanotransistor sensor for the simultaneous measurements of electrical and mechanical cellular responses |
title | Bioinspired two-in-one nanotransistor sensor for the simultaneous measurements of electrical and mechanical cellular responses |
title_full | Bioinspired two-in-one nanotransistor sensor for the simultaneous measurements of electrical and mechanical cellular responses |
title_fullStr | Bioinspired two-in-one nanotransistor sensor for the simultaneous measurements of electrical and mechanical cellular responses |
title_full_unstemmed | Bioinspired two-in-one nanotransistor sensor for the simultaneous measurements of electrical and mechanical cellular responses |
title_short | Bioinspired two-in-one nanotransistor sensor for the simultaneous measurements of electrical and mechanical cellular responses |
title_sort | bioinspired two-in-one nanotransistor sensor for the simultaneous measurements of electrical and mechanical cellular responses |
topic | Physical and Materials Sciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9401615/ https://www.ncbi.nlm.nih.gov/pubmed/36001656 http://dx.doi.org/10.1126/sciadv.abn2485 |
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