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Influence of gestational diabetes mellitus on lipid signatures in breast milk and association with fetal physical development

Gestational diabetes mellitus (GDM) commonly leads to adverse pregnancy outcomes and long-term metabolic complications in offspring. Breastfeeding has been shown to rewrite the fetal “metabolic programming” resulting from maternal diabetes and finally lead to a lower risk of future metabolic disease...

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Autores principales: Zhong, Hong, Zhang, Jiahua, Xia, Jiaai, Zhu, Yuting, Chen, Chen, Shan, Chunjian, Cui, Xianwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9402091/
https://www.ncbi.nlm.nih.gov/pubmed/36034909
http://dx.doi.org/10.3389/fnut.2022.924301
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author Zhong, Hong
Zhang, Jiahua
Xia, Jiaai
Zhu, Yuting
Chen, Chen
Shan, Chunjian
Cui, Xianwei
author_facet Zhong, Hong
Zhang, Jiahua
Xia, Jiaai
Zhu, Yuting
Chen, Chen
Shan, Chunjian
Cui, Xianwei
author_sort Zhong, Hong
collection PubMed
description Gestational diabetes mellitus (GDM) commonly leads to adverse pregnancy outcomes and long-term metabolic complications in offspring. Breastfeeding has been shown to rewrite the fetal “metabolic programming” resulting from maternal diabetes and finally lead to a lower risk of future metabolic disease. Lipids in breast milk act like hormones to promote infant growth and development, but there is minimal information invested thus far in constitution changes of lipids in breast milk, especially in the context of GDM. In the present study, we performed a lipidomics analysis to compare the lipid composition in breast milk collected from women with or without GDM. We further revealed the correlations of dysregulated lipids in breast milk with maternal glucose and infant physical development. A total of 833 lipid species from 15 classes were identified, 60 of which were found to be significantly altered in response to the high glucose, suggesting a remarkable lipid profiling change in breast milk induced by GDM. Our results showed significant associations between dysregulated lipids (e.g., neutral lipids, phospholipids, sphingolipids) and maternal glucose. Furthermore, correction analysis demonstrated that GDM related lipids were also associated with indicators of infant physical development, including body weight, length, and head circumference. These findings may help to understand the protective effects of breastfeeding especially during GDM pregnancy.
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spelling pubmed-94020912022-08-25 Influence of gestational diabetes mellitus on lipid signatures in breast milk and association with fetal physical development Zhong, Hong Zhang, Jiahua Xia, Jiaai Zhu, Yuting Chen, Chen Shan, Chunjian Cui, Xianwei Front Nutr Nutrition Gestational diabetes mellitus (GDM) commonly leads to adverse pregnancy outcomes and long-term metabolic complications in offspring. Breastfeeding has been shown to rewrite the fetal “metabolic programming” resulting from maternal diabetes and finally lead to a lower risk of future metabolic disease. Lipids in breast milk act like hormones to promote infant growth and development, but there is minimal information invested thus far in constitution changes of lipids in breast milk, especially in the context of GDM. In the present study, we performed a lipidomics analysis to compare the lipid composition in breast milk collected from women with or without GDM. We further revealed the correlations of dysregulated lipids in breast milk with maternal glucose and infant physical development. A total of 833 lipid species from 15 classes were identified, 60 of which were found to be significantly altered in response to the high glucose, suggesting a remarkable lipid profiling change in breast milk induced by GDM. Our results showed significant associations between dysregulated lipids (e.g., neutral lipids, phospholipids, sphingolipids) and maternal glucose. Furthermore, correction analysis demonstrated that GDM related lipids were also associated with indicators of infant physical development, including body weight, length, and head circumference. These findings may help to understand the protective effects of breastfeeding especially during GDM pregnancy. Frontiers Media S.A. 2022-08-10 /pmc/articles/PMC9402091/ /pubmed/36034909 http://dx.doi.org/10.3389/fnut.2022.924301 Text en Copyright © 2022 Zhong, Zhang, Xia, Zhu, Chen, Shan and Cui. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Zhong, Hong
Zhang, Jiahua
Xia, Jiaai
Zhu, Yuting
Chen, Chen
Shan, Chunjian
Cui, Xianwei
Influence of gestational diabetes mellitus on lipid signatures in breast milk and association with fetal physical development
title Influence of gestational diabetes mellitus on lipid signatures in breast milk and association with fetal physical development
title_full Influence of gestational diabetes mellitus on lipid signatures in breast milk and association with fetal physical development
title_fullStr Influence of gestational diabetes mellitus on lipid signatures in breast milk and association with fetal physical development
title_full_unstemmed Influence of gestational diabetes mellitus on lipid signatures in breast milk and association with fetal physical development
title_short Influence of gestational diabetes mellitus on lipid signatures in breast milk and association with fetal physical development
title_sort influence of gestational diabetes mellitus on lipid signatures in breast milk and association with fetal physical development
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9402091/
https://www.ncbi.nlm.nih.gov/pubmed/36034909
http://dx.doi.org/10.3389/fnut.2022.924301
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