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Sustained attention induces altered effective connectivity of the ascending thalamo-cortical relay in obsessive-compulsive disorder
Abnormal function of the thalamo-cortical relay is considered a hallmark of obsessive-compulsive disorder (OCD) and aberrant network interactions may underpin many of the clinical and cognitive symptoms that characterize the disorder. Several statistical approaches have been applied to in vivo fMRI...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9402224/ https://www.ncbi.nlm.nih.gov/pubmed/36032258 http://dx.doi.org/10.3389/fpsyt.2022.869106 |
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author | Yacou, Mario A. Chowdury, Asadur Easter, Philip Hanna, Gregory L. Rosenberg, David R. Diwadkar, Vaibhav A. |
author_facet | Yacou, Mario A. Chowdury, Asadur Easter, Philip Hanna, Gregory L. Rosenberg, David R. Diwadkar, Vaibhav A. |
author_sort | Yacou, Mario A. |
collection | PubMed |
description | Abnormal function of the thalamo-cortical relay is considered a hallmark of obsessive-compulsive disorder (OCD) and aberrant network interactions may underpin many of the clinical and cognitive symptoms that characterize the disorder. Several statistical approaches have been applied to in vivo fMRI data to support the general loss of thalamo-cortical connectivity in OCD. However, (a) few studies have assessed the contextual constraints under which abnormal network interactions arise or (b) have used methods of effective connectivity to understand abnormal network interactions. Effective connectivity is a particularly valuable method as it describes the putative causal influences that brain regions exert over each other, as opposed to the largely statistical consistencies captured in functional connectivity techniques. Here, using dynamic causal modeling (DCM), we evaluated how attention demand induced inter-group differences (HC ≠ OCD) in effective connectivity within a motivated thalamo-cortical network. Of interest was whether these effects were observed on the ascending thalamo-cortical relay, essential for the sensory innervation of the cortex. fMRI time series data from sixty-two participants (OCD, 30; HC, 32) collected using an established sustained attention task were submitted to a space of 162 competing models. Across the space, models distinguished between competing hypotheses of thalamo-cortical interactions. Bayesian model selection (BMS) identified marginally differing likely generative model architectures in OCD and HC groups. Bayesian model averaging (BMA), was used to weight connectivity parameter estimates across all models, with each parameter weighted by each model’s posterior probability, thus providing more stable estimates of effective connectivity. Inferential statistical analyses of estimated parameters revealed two principal results: (1) Significantly reduced intrinsic connectivity of the V1 → SPC pathway in OCD, suggested connective weakness in the early constituents of the dorsal visual pathway; (2) More pertinent with the discovery possibilities afforded by DCM, sustained attention in OCD patients induced significantly reduced contextual modulation of the ascending relay from the thalamus to the prefrontal cortex. These results form an important complement to our understanding of the contextual bases of thalamo-cortical network deficits in OCD, emphasizing vulnerability of the ascending relay. |
format | Online Article Text |
id | pubmed-9402224 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94022242022-08-25 Sustained attention induces altered effective connectivity of the ascending thalamo-cortical relay in obsessive-compulsive disorder Yacou, Mario A. Chowdury, Asadur Easter, Philip Hanna, Gregory L. Rosenberg, David R. Diwadkar, Vaibhav A. Front Psychiatry Psychiatry Abnormal function of the thalamo-cortical relay is considered a hallmark of obsessive-compulsive disorder (OCD) and aberrant network interactions may underpin many of the clinical and cognitive symptoms that characterize the disorder. Several statistical approaches have been applied to in vivo fMRI data to support the general loss of thalamo-cortical connectivity in OCD. However, (a) few studies have assessed the contextual constraints under which abnormal network interactions arise or (b) have used methods of effective connectivity to understand abnormal network interactions. Effective connectivity is a particularly valuable method as it describes the putative causal influences that brain regions exert over each other, as opposed to the largely statistical consistencies captured in functional connectivity techniques. Here, using dynamic causal modeling (DCM), we evaluated how attention demand induced inter-group differences (HC ≠ OCD) in effective connectivity within a motivated thalamo-cortical network. Of interest was whether these effects were observed on the ascending thalamo-cortical relay, essential for the sensory innervation of the cortex. fMRI time series data from sixty-two participants (OCD, 30; HC, 32) collected using an established sustained attention task were submitted to a space of 162 competing models. Across the space, models distinguished between competing hypotheses of thalamo-cortical interactions. Bayesian model selection (BMS) identified marginally differing likely generative model architectures in OCD and HC groups. Bayesian model averaging (BMA), was used to weight connectivity parameter estimates across all models, with each parameter weighted by each model’s posterior probability, thus providing more stable estimates of effective connectivity. Inferential statistical analyses of estimated parameters revealed two principal results: (1) Significantly reduced intrinsic connectivity of the V1 → SPC pathway in OCD, suggested connective weakness in the early constituents of the dorsal visual pathway; (2) More pertinent with the discovery possibilities afforded by DCM, sustained attention in OCD patients induced significantly reduced contextual modulation of the ascending relay from the thalamus to the prefrontal cortex. These results form an important complement to our understanding of the contextual bases of thalamo-cortical network deficits in OCD, emphasizing vulnerability of the ascending relay. Frontiers Media S.A. 2022-08-10 /pmc/articles/PMC9402224/ /pubmed/36032258 http://dx.doi.org/10.3389/fpsyt.2022.869106 Text en Copyright © 2022 Yacou, Chowdury, Easter, Hanna, Rosenberg and Diwadkar. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Psychiatry Yacou, Mario A. Chowdury, Asadur Easter, Philip Hanna, Gregory L. Rosenberg, David R. Diwadkar, Vaibhav A. Sustained attention induces altered effective connectivity of the ascending thalamo-cortical relay in obsessive-compulsive disorder |
title | Sustained attention induces altered effective connectivity of the ascending thalamo-cortical relay in obsessive-compulsive disorder |
title_full | Sustained attention induces altered effective connectivity of the ascending thalamo-cortical relay in obsessive-compulsive disorder |
title_fullStr | Sustained attention induces altered effective connectivity of the ascending thalamo-cortical relay in obsessive-compulsive disorder |
title_full_unstemmed | Sustained attention induces altered effective connectivity of the ascending thalamo-cortical relay in obsessive-compulsive disorder |
title_short | Sustained attention induces altered effective connectivity of the ascending thalamo-cortical relay in obsessive-compulsive disorder |
title_sort | sustained attention induces altered effective connectivity of the ascending thalamo-cortical relay in obsessive-compulsive disorder |
topic | Psychiatry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9402224/ https://www.ncbi.nlm.nih.gov/pubmed/36032258 http://dx.doi.org/10.3389/fpsyt.2022.869106 |
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