Significant Reduction in Vaccine-Induced Antibody Levels and Neutralization Activity Among Healthcare Workers and Nursing Home Residents 6 Months Following Coronavirus Disease 2019 BNT162b2 mRNA Vaccination

Antibody decline occurred from 2 weeks to 6 months post-BNT162b2 mRNA vaccination in nursing home (NH) residents and healthcare workers. Antispike, receptor-binding domain, and neutralization levels dropped >81% irrespective of prior infection. Notably, 69% of infection-naive NH residents had neu...

Descripción completa

Detalles Bibliográficos
Autores principales: Canaday, David H, Oyebanji, Oladayo A, Keresztesy, Debbie, Payne, Michael, Wilk, Dennis, Carias, Lenore, Aung, Htin, St. Denis, Kerri, Lam, Evan C, Rowley, Christopher F, Berry, Sarah D, Cameron, Cheryl M, Cameron, Mark J, Wilson, Brigid M, Balazs, Alejandro B, King, Christopher L, Gravenstein, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9402619/
https://www.ncbi.nlm.nih.gov/pubmed/35174389
http://dx.doi.org/10.1093/cid/ciab963
Descripción
Sumario:Antibody decline occurred from 2 weeks to 6 months post-BNT162b2 mRNA vaccination in nursing home (NH) residents and healthcare workers. Antispike, receptor-binding domain, and neutralization levels dropped >81% irrespective of prior infection. Notably, 69% of infection-naive NH residents had neutralizing antibodies at or below the assay’s limit of detection.

Ejemplares similares