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Significant Reduction in Vaccine-Induced Antibody Levels and Neutralization Activity Among Healthcare Workers and Nursing Home Residents 6 Months Following Coronavirus Disease 2019 BNT162b2 mRNA Vaccination
Antibody decline occurred from 2 weeks to 6 months post-BNT162b2 mRNA vaccination in nursing home (NH) residents and healthcare workers. Antispike, receptor-binding domain, and neutralization levels dropped >81% irrespective of prior infection. Notably, 69% of infection-naive NH residents had neu...
| Autores principales: | , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9402619/ https://www.ncbi.nlm.nih.gov/pubmed/35174389 http://dx.doi.org/10.1093/cid/ciab963 |
| _version_ | 1784773212476801024 |
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| author | Canaday, David H Oyebanji, Oladayo A Keresztesy, Debbie Payne, Michael Wilk, Dennis Carias, Lenore Aung, Htin St. Denis, Kerri Lam, Evan C Rowley, Christopher F Berry, Sarah D Cameron, Cheryl M Cameron, Mark J Wilson, Brigid M Balazs, Alejandro B King, Christopher L Gravenstein, Stefan |
| author_facet | Canaday, David H Oyebanji, Oladayo A Keresztesy, Debbie Payne, Michael Wilk, Dennis Carias, Lenore Aung, Htin St. Denis, Kerri Lam, Evan C Rowley, Christopher F Berry, Sarah D Cameron, Cheryl M Cameron, Mark J Wilson, Brigid M Balazs, Alejandro B King, Christopher L Gravenstein, Stefan |
| author_sort | Canaday, David H |
| collection | PubMed |
| description | Antibody decline occurred from 2 weeks to 6 months post-BNT162b2 mRNA vaccination in nursing home (NH) residents and healthcare workers. Antispike, receptor-binding domain, and neutralization levels dropped >81% irrespective of prior infection. Notably, 69% of infection-naive NH residents had neutralizing antibodies at or below the assay’s limit of detection. |
| format | Online Article Text |
| id | pubmed-9402619 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | Oxford University Press |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-94026192022-08-25 Significant Reduction in Vaccine-Induced Antibody Levels and Neutralization Activity Among Healthcare Workers and Nursing Home Residents 6 Months Following Coronavirus Disease 2019 BNT162b2 mRNA Vaccination Canaday, David H Oyebanji, Oladayo A Keresztesy, Debbie Payne, Michael Wilk, Dennis Carias, Lenore Aung, Htin St. Denis, Kerri Lam, Evan C Rowley, Christopher F Berry, Sarah D Cameron, Cheryl M Cameron, Mark J Wilson, Brigid M Balazs, Alejandro B King, Christopher L Gravenstein, Stefan Clin Infect Dis Brief Report Antibody decline occurred from 2 weeks to 6 months post-BNT162b2 mRNA vaccination in nursing home (NH) residents and healthcare workers. Antispike, receptor-binding domain, and neutralization levels dropped >81% irrespective of prior infection. Notably, 69% of infection-naive NH residents had neutralizing antibodies at or below the assay’s limit of detection. Oxford University Press 2021-11-19 /pmc/articles/PMC9402619/ /pubmed/35174389 http://dx.doi.org/10.1093/cid/ciab963 Text en © The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
| spellingShingle | Brief Report Canaday, David H Oyebanji, Oladayo A Keresztesy, Debbie Payne, Michael Wilk, Dennis Carias, Lenore Aung, Htin St. Denis, Kerri Lam, Evan C Rowley, Christopher F Berry, Sarah D Cameron, Cheryl M Cameron, Mark J Wilson, Brigid M Balazs, Alejandro B King, Christopher L Gravenstein, Stefan Significant Reduction in Vaccine-Induced Antibody Levels and Neutralization Activity Among Healthcare Workers and Nursing Home Residents 6 Months Following Coronavirus Disease 2019 BNT162b2 mRNA Vaccination |
| title | Significant Reduction in Vaccine-Induced Antibody Levels and Neutralization Activity Among Healthcare Workers and Nursing Home Residents 6 Months Following Coronavirus Disease 2019 BNT162b2 mRNA Vaccination |
| title_full | Significant Reduction in Vaccine-Induced Antibody Levels and Neutralization Activity Among Healthcare Workers and Nursing Home Residents 6 Months Following Coronavirus Disease 2019 BNT162b2 mRNA Vaccination |
| title_fullStr | Significant Reduction in Vaccine-Induced Antibody Levels and Neutralization Activity Among Healthcare Workers and Nursing Home Residents 6 Months Following Coronavirus Disease 2019 BNT162b2 mRNA Vaccination |
| title_full_unstemmed | Significant Reduction in Vaccine-Induced Antibody Levels and Neutralization Activity Among Healthcare Workers and Nursing Home Residents 6 Months Following Coronavirus Disease 2019 BNT162b2 mRNA Vaccination |
| title_short | Significant Reduction in Vaccine-Induced Antibody Levels and Neutralization Activity Among Healthcare Workers and Nursing Home Residents 6 Months Following Coronavirus Disease 2019 BNT162b2 mRNA Vaccination |
| title_sort | significant reduction in vaccine-induced antibody levels and neutralization activity among healthcare workers and nursing home residents 6 months following coronavirus disease 2019 bnt162b2 mrna vaccination |
| topic | Brief Report |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9402619/ https://www.ncbi.nlm.nih.gov/pubmed/35174389 http://dx.doi.org/10.1093/cid/ciab963 |
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