Stromal remodeling regulates dendritic cell abundance and activity in the tumor microenvironment

Stimulatory type 1 conventional dendritic cells (cDC1s) engage in productive interactions with CD8(+) effectors along tumor-stroma boundaries. The paradoxical accumulation of “poised” cDC1s within stromal sheets is unlikely to simply reflect passive exclusion from tumor cores. Drawing parallels with...

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Detalles Bibliográficos
Autores principales: Papadas, Athanasios, Deb, Gauri, Cicala, Alexander, Officer, Adam, Hope, Chelsea, Pagenkopf, Adam, Flietner, Evan, Morrow, Zachary T., Emmerich, Philip, Wiesner, Joshua, Arauz, Garrett, Bansal, Varun, Esbona, Karla, Capitini, Christian M., Matkowskyj, Kristina A., Deming, Dustin A., Politi, Katerina, Abrams, Scott I., Harismendy, Olivier, Asimakopoulos, Fotis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9402878/
https://www.ncbi.nlm.nih.gov/pubmed/35977482
http://dx.doi.org/10.1016/j.celrep.2022.111201

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