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The 3D genome landscape: Diverse chromosomal interactions and their functional implications

Genome organization includes contacts both within a single chromosome and between distinct chromosomes. Thus, regulatory organization in the nucleus may include interplay of these two types of chromosomal interactions with genome activity. Emerging advances in omics and single-cell imaging technolog...

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Detalles Bibliográficos
Autores principales: Fleck, Katherine, Raj, Romir, Erceg, Jelena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9402908/
https://www.ncbi.nlm.nih.gov/pubmed/36036013
http://dx.doi.org/10.3389/fcell.2022.968145
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author Fleck, Katherine
Raj, Romir
Erceg, Jelena
author_facet Fleck, Katherine
Raj, Romir
Erceg, Jelena
author_sort Fleck, Katherine
collection PubMed
description Genome organization includes contacts both within a single chromosome and between distinct chromosomes. Thus, regulatory organization in the nucleus may include interplay of these two types of chromosomal interactions with genome activity. Emerging advances in omics and single-cell imaging technologies have allowed new insights into chromosomal contacts, including those of homologs and sister chromatids, and their significance to genome function. In this review, we highlight recent studies in this field and discuss their impact on understanding the principles of chromosome organization and associated functional implications in diverse cellular processes. Specifically, we describe the contributions of intra-chromosomal, inter-homolog, and inter-sister chromatid contacts to genome organization and gene expression.
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spelling pubmed-94029082022-08-26 The 3D genome landscape: Diverse chromosomal interactions and their functional implications Fleck, Katherine Raj, Romir Erceg, Jelena Front Cell Dev Biol Cell and Developmental Biology Genome organization includes contacts both within a single chromosome and between distinct chromosomes. Thus, regulatory organization in the nucleus may include interplay of these two types of chromosomal interactions with genome activity. Emerging advances in omics and single-cell imaging technologies have allowed new insights into chromosomal contacts, including those of homologs and sister chromatids, and their significance to genome function. In this review, we highlight recent studies in this field and discuss their impact on understanding the principles of chromosome organization and associated functional implications in diverse cellular processes. Specifically, we describe the contributions of intra-chromosomal, inter-homolog, and inter-sister chromatid contacts to genome organization and gene expression. Frontiers Media S.A. 2022-08-11 /pmc/articles/PMC9402908/ /pubmed/36036013 http://dx.doi.org/10.3389/fcell.2022.968145 Text en Copyright © 2022 Fleck, Raj and Erceg. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Fleck, Katherine
Raj, Romir
Erceg, Jelena
The 3D genome landscape: Diverse chromosomal interactions and their functional implications
title The 3D genome landscape: Diverse chromosomal interactions and their functional implications
title_full The 3D genome landscape: Diverse chromosomal interactions and their functional implications
title_fullStr The 3D genome landscape: Diverse chromosomal interactions and their functional implications
title_full_unstemmed The 3D genome landscape: Diverse chromosomal interactions and their functional implications
title_short The 3D genome landscape: Diverse chromosomal interactions and their functional implications
title_sort 3d genome landscape: diverse chromosomal interactions and their functional implications
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9402908/
https://www.ncbi.nlm.nih.gov/pubmed/36036013
http://dx.doi.org/10.3389/fcell.2022.968145
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