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Development of Nanomaterials to Target Articular Cartilage for Osteoarthritis Therapy
Osteoarthritis (OA) is an obstinate, degradative, and complicated disease that has drawn much attention worldwide. Characterized by its stubborn symptoms and various sequela, OA causes much financial burden on both patients and the health system. What’s more, conventional systematic therapy is not e...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9402910/ https://www.ncbi.nlm.nih.gov/pubmed/36032667 http://dx.doi.org/10.3389/fmolb.2022.900344 |
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author | Rao, Chenyu Shi, Sirong |
author_facet | Rao, Chenyu Shi, Sirong |
author_sort | Rao, Chenyu |
collection | PubMed |
description | Osteoarthritis (OA) is an obstinate, degradative, and complicated disease that has drawn much attention worldwide. Characterized by its stubborn symptoms and various sequela, OA causes much financial burden on both patients and the health system. What’s more, conventional systematic therapy is not effective enough and causes multiple side effects. There’s much evidence that nanoparticles have unique properties such as high penetration, biostability, and large specific surface area. Thus, it is urgent to exploit novel medications for OA. Nanomaterials have been sufficiently studied, exploiting diverse nano-drug delivery systems (DDSs) and targeted nano therapeutical molecules. The nanomaterials are primarily intra-articular injected under the advantages of high topical concentration and low dosage. After administration, the DDS and targeted nano therapeutical molecules can specifically react with the components, including cartilage and synovium of a joint in OA, furthermore attenuate the chondrocyte apoptosis, matrix degradation, and macrophage recruitment. Thus, arthritis would be alleviated. The DDSs could load with conventional anti-inflammatory drugs, antibodies, RNA, and so on, targeting chondrocytes, synovium, or extracellular matrix (ECM) and releasing the molecules sequentially. The targeted nano therapeutical molecules could directly get to the targeted tissue, alleviating the inflammation and promoting tissue healing. This review will comprehensively collect and evaluate the targeted nanomaterials to articular cartilage in OA. |
format | Online Article Text |
id | pubmed-9402910 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94029102022-08-26 Development of Nanomaterials to Target Articular Cartilage for Osteoarthritis Therapy Rao, Chenyu Shi, Sirong Front Mol Biosci Molecular Biosciences Osteoarthritis (OA) is an obstinate, degradative, and complicated disease that has drawn much attention worldwide. Characterized by its stubborn symptoms and various sequela, OA causes much financial burden on both patients and the health system. What’s more, conventional systematic therapy is not effective enough and causes multiple side effects. There’s much evidence that nanoparticles have unique properties such as high penetration, biostability, and large specific surface area. Thus, it is urgent to exploit novel medications for OA. Nanomaterials have been sufficiently studied, exploiting diverse nano-drug delivery systems (DDSs) and targeted nano therapeutical molecules. The nanomaterials are primarily intra-articular injected under the advantages of high topical concentration and low dosage. After administration, the DDS and targeted nano therapeutical molecules can specifically react with the components, including cartilage and synovium of a joint in OA, furthermore attenuate the chondrocyte apoptosis, matrix degradation, and macrophage recruitment. Thus, arthritis would be alleviated. The DDSs could load with conventional anti-inflammatory drugs, antibodies, RNA, and so on, targeting chondrocytes, synovium, or extracellular matrix (ECM) and releasing the molecules sequentially. The targeted nano therapeutical molecules could directly get to the targeted tissue, alleviating the inflammation and promoting tissue healing. This review will comprehensively collect and evaluate the targeted nanomaterials to articular cartilage in OA. Frontiers Media S.A. 2022-08-11 /pmc/articles/PMC9402910/ /pubmed/36032667 http://dx.doi.org/10.3389/fmolb.2022.900344 Text en Copyright © 2022 Rao and Shi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Molecular Biosciences Rao, Chenyu Shi, Sirong Development of Nanomaterials to Target Articular Cartilage for Osteoarthritis Therapy |
title | Development of Nanomaterials to Target Articular Cartilage for Osteoarthritis Therapy |
title_full | Development of Nanomaterials to Target Articular Cartilage for Osteoarthritis Therapy |
title_fullStr | Development of Nanomaterials to Target Articular Cartilage for Osteoarthritis Therapy |
title_full_unstemmed | Development of Nanomaterials to Target Articular Cartilage for Osteoarthritis Therapy |
title_short | Development of Nanomaterials to Target Articular Cartilage for Osteoarthritis Therapy |
title_sort | development of nanomaterials to target articular cartilage for osteoarthritis therapy |
topic | Molecular Biosciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9402910/ https://www.ncbi.nlm.nih.gov/pubmed/36032667 http://dx.doi.org/10.3389/fmolb.2022.900344 |
work_keys_str_mv | AT raochenyu developmentofnanomaterialstotargetarticularcartilageforosteoarthritistherapy AT shisirong developmentofnanomaterialstotargetarticularcartilageforosteoarthritistherapy |