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Interactions between endoplasmic reticulum stress and extracellular vesicles in multiple diseases

Immune responses can severely perturb endoplasmic reticulum (ER) function. As a protein-folding factory and dynamic calcium storage compartment, the ER plays a pivotal role in resisting pathogens and in the development of autoimmune diseases and various other diseases, including cancer, cardiovascul...

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Autores principales: Ye, Jingyao, Liu, Xuehong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9402983/
https://www.ncbi.nlm.nih.gov/pubmed/36032078
http://dx.doi.org/10.3389/fimmu.2022.955419
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author Ye, Jingyao
Liu, Xuehong
author_facet Ye, Jingyao
Liu, Xuehong
author_sort Ye, Jingyao
collection PubMed
description Immune responses can severely perturb endoplasmic reticulum (ER) function. As a protein-folding factory and dynamic calcium storage compartment, the ER plays a pivotal role in resisting pathogens and in the development of autoimmune diseases and various other diseases, including cancer, cardiovascular, neurological, orthopedic, and liver-related diseases, metabolic disorders, etc. In recent years, an increasing number of studies have shown that extracellular vesicles (EVs) play important roles in these conditions, suggesting that cells carry out some physiological functions through EVs. The formation of EVs is dependent on the ER. ER stress, as a state of protein imbalance, is both a cause and consequence of disease. ER stress promotes the transmission of pathological messages to EVs, which are delivered to target cells and lead to disease development. Moreover, EVs can transmit pathological messages to healthy cells, causing ER stress. This paper reviews the biological functions of EVs in disease, as well as the mechanisms underlying interactions between ER stress and EVs in multiple diseases. In addition, the prospects of these interactions for disease treatment are described.
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spelling pubmed-94029832022-08-26 Interactions between endoplasmic reticulum stress and extracellular vesicles in multiple diseases Ye, Jingyao Liu, Xuehong Front Immunol Immunology Immune responses can severely perturb endoplasmic reticulum (ER) function. As a protein-folding factory and dynamic calcium storage compartment, the ER plays a pivotal role in resisting pathogens and in the development of autoimmune diseases and various other diseases, including cancer, cardiovascular, neurological, orthopedic, and liver-related diseases, metabolic disorders, etc. In recent years, an increasing number of studies have shown that extracellular vesicles (EVs) play important roles in these conditions, suggesting that cells carry out some physiological functions through EVs. The formation of EVs is dependent on the ER. ER stress, as a state of protein imbalance, is both a cause and consequence of disease. ER stress promotes the transmission of pathological messages to EVs, which are delivered to target cells and lead to disease development. Moreover, EVs can transmit pathological messages to healthy cells, causing ER stress. This paper reviews the biological functions of EVs in disease, as well as the mechanisms underlying interactions between ER stress and EVs in multiple diseases. In addition, the prospects of these interactions for disease treatment are described. Frontiers Media S.A. 2022-08-11 /pmc/articles/PMC9402983/ /pubmed/36032078 http://dx.doi.org/10.3389/fimmu.2022.955419 Text en Copyright © 2022 Ye and Liu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Ye, Jingyao
Liu, Xuehong
Interactions between endoplasmic reticulum stress and extracellular vesicles in multiple diseases
title Interactions between endoplasmic reticulum stress and extracellular vesicles in multiple diseases
title_full Interactions between endoplasmic reticulum stress and extracellular vesicles in multiple diseases
title_fullStr Interactions between endoplasmic reticulum stress and extracellular vesicles in multiple diseases
title_full_unstemmed Interactions between endoplasmic reticulum stress and extracellular vesicles in multiple diseases
title_short Interactions between endoplasmic reticulum stress and extracellular vesicles in multiple diseases
title_sort interactions between endoplasmic reticulum stress and extracellular vesicles in multiple diseases
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9402983/
https://www.ncbi.nlm.nih.gov/pubmed/36032078
http://dx.doi.org/10.3389/fimmu.2022.955419
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