Monocyte-derived macrophages aggravate pulmonary vasculitis via cGAS/STING/IFN-mediated nucleic acid sensing

Autoimmune vasculitis is a group of life-threatening diseases, whose underlying pathogenic mechanisms are incompletely understood, hampering development of targeted therapies. Here, we demonstrate that patients suffering from anti-neutrophil cytoplasmic antibodies (ANCA)–associated vasculitis (AAV)...

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Detalles Bibliográficos
Autores principales: Kessler, Nina, Viehmann, Susanne F., Krollmann, Calvin, Mai, Karola, Kirschner, Katharina M., Luksch, Hella, Kotagiri, Prasanti, Böhner, Alexander M.C., Huugen, Dennis, de Oliveira Mann, Carina C., Otten, Simon, Weiss, Stefanie A.I., Zillinger, Thomas, Dobrikova, Kristiyana, Jenne, Dieter E., Behrendt, Rayk, Ablasser, Andrea, Bartok, Eva, Hartmann, Gunther, Hopfner, Karl-Peter, Lyons, Paul A., Boor, Peter, Rösen-Wolff, Angela, Teichmann, Lino L., Heeringa, Peter, Kurts, Christian, Garbi, Natalio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9402992/
https://www.ncbi.nlm.nih.gov/pubmed/35997679
http://dx.doi.org/10.1084/jem.20220759

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