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Thymic epithelial cells require lipid kinase Vps34 for CD4 but not CD8 T cell selection

The generation of a functional, self-tolerant T cell receptor (TCR) repertoire depends on interactions between developing thymocytes and antigen-presenting thymic epithelial cells (TECs). Cortical TECs (cTECs) rely on unique antigen-processing machinery to generate self-peptides specialized for T ce...

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Detalles Bibliográficos
Autores principales:	Postoak, J. Luke, Song, Wenqiang, Yang, Guan, Guo, Xingyi, Xiao, Shiyun, Saffold, Cherie E., Zhang, Jianhua, Joyce, Sebastian, Manley, Nancy R., Wu, Lan, Van Kaer, Luc
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9402993/ https://www.ncbi.nlm.nih.gov/pubmed/35997680 http://dx.doi.org/10.1084/jem.20212554

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