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Compound Kushen injection reduces severity of radiation-induced gastrointestinal mucositis in rats

Mucositis, or damage/injury to mucous membranes of the alimentary, respiratory, or genitourinary tract, is the major side effect associated with anticancer radiotherapies. Because there is no effective treatment for mucositis at present, this is a particular issue as it limits the dose of therapy in...

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Autores principales: Harata-Lee, Yuka, Qu, Zhipeng, Bateman, Emma, Xiao, Xi, Keller, Marianne D., Bowen, Joanne, Wang, Wei, Adelson, David L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9403047/
https://www.ncbi.nlm.nih.gov/pubmed/36033515
http://dx.doi.org/10.3389/fonc.2022.929735
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author Harata-Lee, Yuka
Qu, Zhipeng
Bateman, Emma
Xiao, Xi
Keller, Marianne D.
Bowen, Joanne
Wang, Wei
Adelson, David L.
author_facet Harata-Lee, Yuka
Qu, Zhipeng
Bateman, Emma
Xiao, Xi
Keller, Marianne D.
Bowen, Joanne
Wang, Wei
Adelson, David L.
author_sort Harata-Lee, Yuka
collection PubMed
description Mucositis, or damage/injury to mucous membranes of the alimentary, respiratory, or genitourinary tract, is the major side effect associated with anticancer radiotherapies. Because there is no effective treatment for mucositis at present, this is a particular issue as it limits the dose of therapy in cancer patients and significantly affects their quality of life. Gastrointestinal mucositis (GIM) occurs in patients receiving radiotherapies to treat cancers of the stomach, abdomen, and pelvis. It involves inflammation and ulceration of the gastrointestinal (GI) tract causing diarrhea, nausea and vomiting, abdominal pain, and bloating. However, there is currently no effective treatment for this debilitating condition. In this study, we investigated the potential of a type of traditional Chinese medicine (TCM), compound Kushen injection (CKI), as a treatment for GIM. It has previously been shown that major groups of chemical compounds found in CKI have anti-inflammatory effects and are capable of inhibiting the expression of pro-inflammatory cytokines. Intraperitoneal administration of CKI to Sprague Dawley (SD) rats that concurrently received abdominal irradiation over five fractions resulted in reduced severity of GIM symptoms compared to rats administered a vehicle control. Histological examination of the intestinal tissues revealed significantly less damaged villus epithelium in CKI-administered rats that had reduced numbers of apoptotic cells in the crypts. Furthermore, it was also found that CKI treatment led to decreased levels of inflammatory factors including lower levels of interleukin (IL)-1β and IL-6 as well as myeloperoxidase (MPO)-producing cells in the intestinal mucosa. Together, our data indicate a novel effect of CKI to reduce the symptoms of radiation-induced GIM by inhibiting inflammation in the mucosa and apoptosis of epithelial cells.
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spelling pubmed-94030472022-08-26 Compound Kushen injection reduces severity of radiation-induced gastrointestinal mucositis in rats Harata-Lee, Yuka Qu, Zhipeng Bateman, Emma Xiao, Xi Keller, Marianne D. Bowen, Joanne Wang, Wei Adelson, David L. Front Oncol Oncology Mucositis, or damage/injury to mucous membranes of the alimentary, respiratory, or genitourinary tract, is the major side effect associated with anticancer radiotherapies. Because there is no effective treatment for mucositis at present, this is a particular issue as it limits the dose of therapy in cancer patients and significantly affects their quality of life. Gastrointestinal mucositis (GIM) occurs in patients receiving radiotherapies to treat cancers of the stomach, abdomen, and pelvis. It involves inflammation and ulceration of the gastrointestinal (GI) tract causing diarrhea, nausea and vomiting, abdominal pain, and bloating. However, there is currently no effective treatment for this debilitating condition. In this study, we investigated the potential of a type of traditional Chinese medicine (TCM), compound Kushen injection (CKI), as a treatment for GIM. It has previously been shown that major groups of chemical compounds found in CKI have anti-inflammatory effects and are capable of inhibiting the expression of pro-inflammatory cytokines. Intraperitoneal administration of CKI to Sprague Dawley (SD) rats that concurrently received abdominal irradiation over five fractions resulted in reduced severity of GIM symptoms compared to rats administered a vehicle control. Histological examination of the intestinal tissues revealed significantly less damaged villus epithelium in CKI-administered rats that had reduced numbers of apoptotic cells in the crypts. Furthermore, it was also found that CKI treatment led to decreased levels of inflammatory factors including lower levels of interleukin (IL)-1β and IL-6 as well as myeloperoxidase (MPO)-producing cells in the intestinal mucosa. Together, our data indicate a novel effect of CKI to reduce the symptoms of radiation-induced GIM by inhibiting inflammation in the mucosa and apoptosis of epithelial cells. Frontiers Media S.A. 2022-08-11 /pmc/articles/PMC9403047/ /pubmed/36033515 http://dx.doi.org/10.3389/fonc.2022.929735 Text en Copyright © 2022 Harata-Lee, Qu, Bateman, Xiao, Keller, Bowen, Wang and Adelson https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Harata-Lee, Yuka
Qu, Zhipeng
Bateman, Emma
Xiao, Xi
Keller, Marianne D.
Bowen, Joanne
Wang, Wei
Adelson, David L.
Compound Kushen injection reduces severity of radiation-induced gastrointestinal mucositis in rats
title Compound Kushen injection reduces severity of radiation-induced gastrointestinal mucositis in rats
title_full Compound Kushen injection reduces severity of radiation-induced gastrointestinal mucositis in rats
title_fullStr Compound Kushen injection reduces severity of radiation-induced gastrointestinal mucositis in rats
title_full_unstemmed Compound Kushen injection reduces severity of radiation-induced gastrointestinal mucositis in rats
title_short Compound Kushen injection reduces severity of radiation-induced gastrointestinal mucositis in rats
title_sort compound kushen injection reduces severity of radiation-induced gastrointestinal mucositis in rats
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9403047/
https://www.ncbi.nlm.nih.gov/pubmed/36033515
http://dx.doi.org/10.3389/fonc.2022.929735
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