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Seizure outcomes and prognostic factors in patients with gangliogliomas associated with epilepsy

INTRODUCTION: Ganglioglioma (GG) patients often present with seizures. Although most patients can be seizure-free after tumor resection, some still experience seizures. The present study aimed to analyze a group of GGs patients associated with epilepsy and evaluate the seizure outcomes and prognosti...

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Autores principales: Hu, Yue, Zhang, Huawei, Adilijiang, Aihemaitiniyazi, Zhou, Jian, Guan, Yuguang, Qi, Xueling, Wang, Mengyang, Wang, Jing, Wang, Xiongfei, Liu, Changqing, Luan, Guoming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9403059/
https://www.ncbi.nlm.nih.gov/pubmed/36034348
http://dx.doi.org/10.3389/fsurg.2022.946201
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author Hu, Yue
Zhang, Huawei
Adilijiang, Aihemaitiniyazi
Zhou, Jian
Guan, Yuguang
Qi, Xueling
Wang, Mengyang
Wang, Jing
Wang, Xiongfei
Liu, Changqing
Luan, Guoming
author_facet Hu, Yue
Zhang, Huawei
Adilijiang, Aihemaitiniyazi
Zhou, Jian
Guan, Yuguang
Qi, Xueling
Wang, Mengyang
Wang, Jing
Wang, Xiongfei
Liu, Changqing
Luan, Guoming
author_sort Hu, Yue
collection PubMed
description INTRODUCTION: Ganglioglioma (GG) patients often present with seizures. Although most patients can be seizure-free after tumor resection, some still experience seizures. The present study aimed to analyze a group of GGs patients associated with epilepsy and evaluate the seizure outcomes and prognostic factors. METHODS: This retrospective study involved clinical data collected from medical records of patients diagnosed with GG pathologically and underwent surgical resection in Sanbo Brain Hospital, Capital Medical University. The seizure outcomes were evaluated based on the International League Against Epilepsy (ILAE) seizure outcome classification. The prognostic factors were identified according to univariate and multivariate analysis. RESULTS: A total of 222 patients were included, with a mean age at surgery of 19.19 ± 10.93 years. All patients were followed up at least for one year with a mean follow-up duration of 6.28 ± 3.17 years. At the final follow-up, 174 (78.4%) patients achieved ILAE Class 1 or 2. Univariate and multivariate analyses revealed that the short duration of seizures and gross total resection were significant positive factors for seizure-free. Bilateral interictal or ictal epileptiform discharges in preoperative video-electroencephalogram (VEEG) were related to poor seizure outcomes. CONCLUSION: Surgical resection is an effective treatment for patients with epilepsy associated with GGs. The analysis of predictive factors could effectively guide clinical practice and evaluate the prognosis of epilepsy with GG.
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spelling pubmed-94030592022-08-26 Seizure outcomes and prognostic factors in patients with gangliogliomas associated with epilepsy Hu, Yue Zhang, Huawei Adilijiang, Aihemaitiniyazi Zhou, Jian Guan, Yuguang Qi, Xueling Wang, Mengyang Wang, Jing Wang, Xiongfei Liu, Changqing Luan, Guoming Front Surg Surgery INTRODUCTION: Ganglioglioma (GG) patients often present with seizures. Although most patients can be seizure-free after tumor resection, some still experience seizures. The present study aimed to analyze a group of GGs patients associated with epilepsy and evaluate the seizure outcomes and prognostic factors. METHODS: This retrospective study involved clinical data collected from medical records of patients diagnosed with GG pathologically and underwent surgical resection in Sanbo Brain Hospital, Capital Medical University. The seizure outcomes were evaluated based on the International League Against Epilepsy (ILAE) seizure outcome classification. The prognostic factors were identified according to univariate and multivariate analysis. RESULTS: A total of 222 patients were included, with a mean age at surgery of 19.19 ± 10.93 years. All patients were followed up at least for one year with a mean follow-up duration of 6.28 ± 3.17 years. At the final follow-up, 174 (78.4%) patients achieved ILAE Class 1 or 2. Univariate and multivariate analyses revealed that the short duration of seizures and gross total resection were significant positive factors for seizure-free. Bilateral interictal or ictal epileptiform discharges in preoperative video-electroencephalogram (VEEG) were related to poor seizure outcomes. CONCLUSION: Surgical resection is an effective treatment for patients with epilepsy associated with GGs. The analysis of predictive factors could effectively guide clinical practice and evaluate the prognosis of epilepsy with GG. Frontiers Media S.A. 2022-08-11 /pmc/articles/PMC9403059/ /pubmed/36034348 http://dx.doi.org/10.3389/fsurg.2022.946201 Text en © 2022 Hu, Zhang, Adilijiang, Zhou, Guan, Qi, Wang, Wang, Wang, Liu and Luan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Surgery
Hu, Yue
Zhang, Huawei
Adilijiang, Aihemaitiniyazi
Zhou, Jian
Guan, Yuguang
Qi, Xueling
Wang, Mengyang
Wang, Jing
Wang, Xiongfei
Liu, Changqing
Luan, Guoming
Seizure outcomes and prognostic factors in patients with gangliogliomas associated with epilepsy
title Seizure outcomes and prognostic factors in patients with gangliogliomas associated with epilepsy
title_full Seizure outcomes and prognostic factors in patients with gangliogliomas associated with epilepsy
title_fullStr Seizure outcomes and prognostic factors in patients with gangliogliomas associated with epilepsy
title_full_unstemmed Seizure outcomes and prognostic factors in patients with gangliogliomas associated with epilepsy
title_short Seizure outcomes and prognostic factors in patients with gangliogliomas associated with epilepsy
title_sort seizure outcomes and prognostic factors in patients with gangliogliomas associated with epilepsy
topic Surgery
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9403059/
https://www.ncbi.nlm.nih.gov/pubmed/36034348
http://dx.doi.org/10.3389/fsurg.2022.946201
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