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Separating the effects of childhood and adult body size on inflammatory arthritis: a Mendelian randomisation study
OBJECTIVES: Using Mendelian randomisation (MR), we examined whether childhood body size affects risk of rheumatoid arthritis (RA), ankylosing spondylitis (AS), psoriatic arthritis (PsA), gout and systemic lupus erythematosus (SLE) after accounting for the effect of adult body size. METHODS: Genetic...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9403135/ https://www.ncbi.nlm.nih.gov/pubmed/35995490 http://dx.doi.org/10.1136/rmdopen-2022-002321 |
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author | Zhao, Sizheng Steven Bowes, John Barton, Anne Davey Smith, George Richardson, Tom |
author_facet | Zhao, Sizheng Steven Bowes, John Barton, Anne Davey Smith, George Richardson, Tom |
author_sort | Zhao, Sizheng Steven |
collection | PubMed |
description | OBJECTIVES: Using Mendelian randomisation (MR), we examined whether childhood body size affects risk of rheumatoid arthritis (RA), ankylosing spondylitis (AS), psoriatic arthritis (PsA), gout and systemic lupus erythematosus (SLE) after accounting for the effect of adult body size. METHODS: Genetic instruments for childhood (age 10 years) and adult body size were derived using data from 453 169 individuals from the UK Biobank study (313 and 580 variants respectively), which have been previously validated using body mass index data from three independent populations. Genome-wide association data comprised 22 350 RA, 9069 AS, 3609 PsA, 13 179 gout and 5201 SLE cases. For each outcome, we conducted univariable MR to estimate the total effects of childhood and adult body size, and multivariable MR to examine the independent effect of childhood body size after accounting for adult body size. RESULTS: Genetically predicted childhood body size had a total effect on risk of PsA (OR 2.18 per change in body size category; 95% CI 1.43 to 3.31), gout (OR 2.18; 95% CI 1.43 to 3.31) and SLE (OR 2.44; 95% CI 1.14 to 5.22), but not RA (OR 0.95; 95% CI 0.70 to 1.29) or AS (OR 0.96; 95% CI 0.61 to 1.52). After accounting for adult body size, the direct effect of childhood body size was little changed for PsA (OR 1.92; 1.14 to 3.25) and SLE (OR 2.69; 1.24 to 5.87) but was attenuated for gout (OR 1.40; 95% CI 0.94 to 2.09). CONCLUSIONS: Our findings suggest that, for PsA and SLE, the risk conferred from having a larger body size during childhood may not be fully reversable even when a healthy size is achieved in adulthood. |
format | Online Article Text |
id | pubmed-9403135 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-94031352022-09-06 Separating the effects of childhood and adult body size on inflammatory arthritis: a Mendelian randomisation study Zhao, Sizheng Steven Bowes, John Barton, Anne Davey Smith, George Richardson, Tom RMD Open Epidemiology OBJECTIVES: Using Mendelian randomisation (MR), we examined whether childhood body size affects risk of rheumatoid arthritis (RA), ankylosing spondylitis (AS), psoriatic arthritis (PsA), gout and systemic lupus erythematosus (SLE) after accounting for the effect of adult body size. METHODS: Genetic instruments for childhood (age 10 years) and adult body size were derived using data from 453 169 individuals from the UK Biobank study (313 and 580 variants respectively), which have been previously validated using body mass index data from three independent populations. Genome-wide association data comprised 22 350 RA, 9069 AS, 3609 PsA, 13 179 gout and 5201 SLE cases. For each outcome, we conducted univariable MR to estimate the total effects of childhood and adult body size, and multivariable MR to examine the independent effect of childhood body size after accounting for adult body size. RESULTS: Genetically predicted childhood body size had a total effect on risk of PsA (OR 2.18 per change in body size category; 95% CI 1.43 to 3.31), gout (OR 2.18; 95% CI 1.43 to 3.31) and SLE (OR 2.44; 95% CI 1.14 to 5.22), but not RA (OR 0.95; 95% CI 0.70 to 1.29) or AS (OR 0.96; 95% CI 0.61 to 1.52). After accounting for adult body size, the direct effect of childhood body size was little changed for PsA (OR 1.92; 1.14 to 3.25) and SLE (OR 2.69; 1.24 to 5.87) but was attenuated for gout (OR 1.40; 95% CI 0.94 to 2.09). CONCLUSIONS: Our findings suggest that, for PsA and SLE, the risk conferred from having a larger body size during childhood may not be fully reversable even when a healthy size is achieved in adulthood. BMJ Publishing Group 2022-08-22 /pmc/articles/PMC9403135/ /pubmed/35995490 http://dx.doi.org/10.1136/rmdopen-2022-002321 Text en © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Epidemiology Zhao, Sizheng Steven Bowes, John Barton, Anne Davey Smith, George Richardson, Tom Separating the effects of childhood and adult body size on inflammatory arthritis: a Mendelian randomisation study |
title | Separating the effects of childhood and adult body size on inflammatory arthritis: a Mendelian randomisation study |
title_full | Separating the effects of childhood and adult body size on inflammatory arthritis: a Mendelian randomisation study |
title_fullStr | Separating the effects of childhood and adult body size on inflammatory arthritis: a Mendelian randomisation study |
title_full_unstemmed | Separating the effects of childhood and adult body size on inflammatory arthritis: a Mendelian randomisation study |
title_short | Separating the effects of childhood and adult body size on inflammatory arthritis: a Mendelian randomisation study |
title_sort | separating the effects of childhood and adult body size on inflammatory arthritis: a mendelian randomisation study |
topic | Epidemiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9403135/ https://www.ncbi.nlm.nih.gov/pubmed/35995490 http://dx.doi.org/10.1136/rmdopen-2022-002321 |
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