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Hepatic Amyloidosis as a Rare Cause of Liver Failure: A Case Report

Amyloidosis is a systemic disease that results from the extracellular deposition of an abnormal protein called amyloid. The kidney and the heart are the most common organ affected by amyloidosis while in some cases liver involvement can be seen. Our patient is a 60-year-old African American male who...

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Autores principales: Ghazanfar, Haider, Khaja, Misbahuddin, Haider, Asim, Yapor, Laura, Kandhi, Sameer, Sulh, Muhammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9403217/
https://www.ncbi.nlm.nih.gov/pubmed/36039232
http://dx.doi.org/10.7759/cureus.27274
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author Ghazanfar, Haider
Khaja, Misbahuddin
Haider, Asim
Yapor, Laura
Kandhi, Sameer
Sulh, Muhammad
author_facet Ghazanfar, Haider
Khaja, Misbahuddin
Haider, Asim
Yapor, Laura
Kandhi, Sameer
Sulh, Muhammad
author_sort Ghazanfar, Haider
collection PubMed
description Amyloidosis is a systemic disease that results from the extracellular deposition of an abnormal protein called amyloid. The kidney and the heart are the most common organ affected by amyloidosis while in some cases liver involvement can be seen. Our patient is a 60-year-old African American male who presented to the emergency department because of multiple episodes of syncope over the past day. Chest x-ray and ultrasound chest were suggestive of pleural effusion for which thoracentesis was done. His hospital course was complicated with renal and liver failure. Computed tomography (CT) abdomen and pelvis was done which showed mild hepatomegaly. Liver biopsy was done which showed congo red stain positive for amyloid. The patient's clinical condition continued to worsen and he was started on hemodialysis. During hospital course, the patient developed liver failure. His family members opted for palliative care and the patient passed away during the same admission. Physicians need to be aware of the detrimental course and poor prognosis associated with hepatic and renal amyloidosis. High clinical suspicion is needed to make an early diagnosis and initiate prompt treatment. Although clinical, laboratory and radiological findings can help in suggesting amyloidosis, a tissue biopsy is needed to confirm the diagnosis of amyloidosis.
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spelling pubmed-94032172022-08-28 Hepatic Amyloidosis as a Rare Cause of Liver Failure: A Case Report Ghazanfar, Haider Khaja, Misbahuddin Haider, Asim Yapor, Laura Kandhi, Sameer Sulh, Muhammad Cureus Internal Medicine Amyloidosis is a systemic disease that results from the extracellular deposition of an abnormal protein called amyloid. The kidney and the heart are the most common organ affected by amyloidosis while in some cases liver involvement can be seen. Our patient is a 60-year-old African American male who presented to the emergency department because of multiple episodes of syncope over the past day. Chest x-ray and ultrasound chest were suggestive of pleural effusion for which thoracentesis was done. His hospital course was complicated with renal and liver failure. Computed tomography (CT) abdomen and pelvis was done which showed mild hepatomegaly. Liver biopsy was done which showed congo red stain positive for amyloid. The patient's clinical condition continued to worsen and he was started on hemodialysis. During hospital course, the patient developed liver failure. His family members opted for palliative care and the patient passed away during the same admission. Physicians need to be aware of the detrimental course and poor prognosis associated with hepatic and renal amyloidosis. High clinical suspicion is needed to make an early diagnosis and initiate prompt treatment. Although clinical, laboratory and radiological findings can help in suggesting amyloidosis, a tissue biopsy is needed to confirm the diagnosis of amyloidosis. Cureus 2022-07-26 /pmc/articles/PMC9403217/ /pubmed/36039232 http://dx.doi.org/10.7759/cureus.27274 Text en Copyright © 2022, Ghazanfar et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Ghazanfar, Haider
Khaja, Misbahuddin
Haider, Asim
Yapor, Laura
Kandhi, Sameer
Sulh, Muhammad
Hepatic Amyloidosis as a Rare Cause of Liver Failure: A Case Report
title Hepatic Amyloidosis as a Rare Cause of Liver Failure: A Case Report
title_full Hepatic Amyloidosis as a Rare Cause of Liver Failure: A Case Report
title_fullStr Hepatic Amyloidosis as a Rare Cause of Liver Failure: A Case Report
title_full_unstemmed Hepatic Amyloidosis as a Rare Cause of Liver Failure: A Case Report
title_short Hepatic Amyloidosis as a Rare Cause of Liver Failure: A Case Report
title_sort hepatic amyloidosis as a rare cause of liver failure: a case report
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9403217/
https://www.ncbi.nlm.nih.gov/pubmed/36039232
http://dx.doi.org/10.7759/cureus.27274
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