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Nano-Microemulsions of CaCO(3)-Encapsulated Curcumin Ester Derivatives With High Antioxidant and Antimicrobial Activities and pH Sensitivity

In this study, we synthesized nano-microemulsions of calcium carbonate (CaCO(3))-encapsulated curcumin (Cur)-Ferulic acid (FA) ester derivatives of diverse mass ratios by using the solution casting approach. The structures, antioxidant and antimicrobial activities, physical properties, and potential...

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Detalles Bibliográficos
Autores principales: Wang, Lian, Wang, Xuefei, Guo, Zhiwei, Xia, Yajuan, Geng, Minjie, Liu, Dan, Zhang, Zhiqiang, Yang, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9403415/
https://www.ncbi.nlm.nih.gov/pubmed/36032301
http://dx.doi.org/10.3389/fvets.2022.857064
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author Wang, Lian
Wang, Xuefei
Guo, Zhiwei
Xia, Yajuan
Geng, Minjie
Liu, Dan
Zhang, Zhiqiang
Yang, Ying
author_facet Wang, Lian
Wang, Xuefei
Guo, Zhiwei
Xia, Yajuan
Geng, Minjie
Liu, Dan
Zhang, Zhiqiang
Yang, Ying
author_sort Wang, Lian
collection PubMed
description In this study, we synthesized nano-microemulsions of calcium carbonate (CaCO(3))-encapsulated curcumin (Cur)-Ferulic acid (FA) ester derivatives of diverse mass ratios by using the solution casting approach. The structures, antioxidant and antimicrobial activities, physical properties, and potential of hydrogen (pH) sensitivity of these products were examined. Compared with microparticles of CaCO(3), those of CaCO(3)@Cur-FA exhibited excellent antimicrobial and antioxidant properties. Response to pH was indicated through the release of Cur-FA from CaCO(3)@Cur-FA in solutions having different pH values. The results demonstrated that Cur-FA was released more quickly from CaCO(3)@Cur-FA at pH 5.5 than at pH 7.4. CaCO(3)@Cur-FA demonstrated good antioxidant capacities through its ability to scavenge 2,2′-amino-di(2-ethyl-benzothiazoline sulphonic acid-6)ammonium salt (ABTS(+)) and 1,1-diphenyl-2-picrylhydrazyl (DPPH). These activities were three-fold more than those observed in CaCO(3) microparticle control groups; additionally, the antimicrobial activity against Aspergillus niger and Escherichia coli increased by 40.5 and 54.6%, respectively. Overall, the microparticles of CaCO(3)@Cur-FA outperformed Cur-FA in terms of antimicrobial properties by inhibiting the growth of certain zoonotic pathogens.
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spelling pubmed-94034152022-08-26 Nano-Microemulsions of CaCO(3)-Encapsulated Curcumin Ester Derivatives With High Antioxidant and Antimicrobial Activities and pH Sensitivity Wang, Lian Wang, Xuefei Guo, Zhiwei Xia, Yajuan Geng, Minjie Liu, Dan Zhang, Zhiqiang Yang, Ying Front Vet Sci Veterinary Science In this study, we synthesized nano-microemulsions of calcium carbonate (CaCO(3))-encapsulated curcumin (Cur)-Ferulic acid (FA) ester derivatives of diverse mass ratios by using the solution casting approach. The structures, antioxidant and antimicrobial activities, physical properties, and potential of hydrogen (pH) sensitivity of these products were examined. Compared with microparticles of CaCO(3), those of CaCO(3)@Cur-FA exhibited excellent antimicrobial and antioxidant properties. Response to pH was indicated through the release of Cur-FA from CaCO(3)@Cur-FA in solutions having different pH values. The results demonstrated that Cur-FA was released more quickly from CaCO(3)@Cur-FA at pH 5.5 than at pH 7.4. CaCO(3)@Cur-FA demonstrated good antioxidant capacities through its ability to scavenge 2,2′-amino-di(2-ethyl-benzothiazoline sulphonic acid-6)ammonium salt (ABTS(+)) and 1,1-diphenyl-2-picrylhydrazyl (DPPH). These activities were three-fold more than those observed in CaCO(3) microparticle control groups; additionally, the antimicrobial activity against Aspergillus niger and Escherichia coli increased by 40.5 and 54.6%, respectively. Overall, the microparticles of CaCO(3)@Cur-FA outperformed Cur-FA in terms of antimicrobial properties by inhibiting the growth of certain zoonotic pathogens. Frontiers Media S.A. 2022-08-11 /pmc/articles/PMC9403415/ /pubmed/36032301 http://dx.doi.org/10.3389/fvets.2022.857064 Text en Copyright © 2022 Wang, Wang, Guo, Xia, Geng, Liu, Zhang and Yang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Wang, Lian
Wang, Xuefei
Guo, Zhiwei
Xia, Yajuan
Geng, Minjie
Liu, Dan
Zhang, Zhiqiang
Yang, Ying
Nano-Microemulsions of CaCO(3)-Encapsulated Curcumin Ester Derivatives With High Antioxidant and Antimicrobial Activities and pH Sensitivity
title Nano-Microemulsions of CaCO(3)-Encapsulated Curcumin Ester Derivatives With High Antioxidant and Antimicrobial Activities and pH Sensitivity
title_full Nano-Microemulsions of CaCO(3)-Encapsulated Curcumin Ester Derivatives With High Antioxidant and Antimicrobial Activities and pH Sensitivity
title_fullStr Nano-Microemulsions of CaCO(3)-Encapsulated Curcumin Ester Derivatives With High Antioxidant and Antimicrobial Activities and pH Sensitivity
title_full_unstemmed Nano-Microemulsions of CaCO(3)-Encapsulated Curcumin Ester Derivatives With High Antioxidant and Antimicrobial Activities and pH Sensitivity
title_short Nano-Microemulsions of CaCO(3)-Encapsulated Curcumin Ester Derivatives With High Antioxidant and Antimicrobial Activities and pH Sensitivity
title_sort nano-microemulsions of caco(3)-encapsulated curcumin ester derivatives with high antioxidant and antimicrobial activities and ph sensitivity
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9403415/
https://www.ncbi.nlm.nih.gov/pubmed/36032301
http://dx.doi.org/10.3389/fvets.2022.857064
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