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Comparison of laboratory characteristics of gastrointestinal symptoms and nongastrointestinal symptoms in patients infected with COVID-19: a systematic review and meta-analysis

BACKGROUND: The Coronavirus Disease 2019 (COVID-19) pandemic poses a massive crisis to global public health. Gastrointestinal (GI) symptoms are increasingly reported in COVID-19. The characteristics of laboratory findings of COVID-19 are critical for clinical diagnosis and treatment. OBJECTIVES: The...

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Autores principales: Zhao, Rui, Shi, Jie, Song, Yichuan, Zhang, Rui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9403443/
https://www.ncbi.nlm.nih.gov/pubmed/36035309
http://dx.doi.org/10.1177/17562848221116264
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author Zhao, Rui
Shi, Jie
Song, Yichuan
Zhang, Rui
author_facet Zhao, Rui
Shi, Jie
Song, Yichuan
Zhang, Rui
author_sort Zhao, Rui
collection PubMed
description BACKGROUND: The Coronavirus Disease 2019 (COVID-19) pandemic poses a massive crisis to global public health. Gastrointestinal (GI) symptoms are increasingly reported in COVID-19. The characteristics of laboratory findings of COVID-19 are critical for clinical diagnosis and treatment. OBJECTIVES: The study aimed to summarize laboratory features in COVID-19 with GI symptoms and non-GI symptoms. DESIGN: This study was a systematic review and meta-analysis. Electronic literature searches were conducted for studies that included patients infected COVID-19 with GI symptoms and non-GI symptoms. GI symptoms included diarrhea, abdominal pain, nausea and vomiting, and anorexia. This study used a random-effects model to assess pooled data. DATA SOURCES AND METHODS: We systematically searched PubMed, Embase, Cochrane, Web of Science for studies through 31 October 2021, with no language restrictions. We used the following search terms: ‘COVID-19’ OR ‘2019-nCoV’ OR ‘SARS-CoV-2’ OR ‘coronavirus 2019’ OR ‘severe acute respiratory syndrome coronavirus 2’ OR ‘coronavirus’ OR ‘novel coronavirus’ OR ‘nCoV’ AND ‘gastrointestinal symptoms’ OR ‘digestive symptoms’ AND ‘clinical feature’ OR ‘clinical characteristics.’ Data mostly originated from Chinese and American studies. RESULTS: Of 796 identified studies, 14 were eligible and were included in our analysis (N = 8396 participants). Meta-analysis showed that GI symptoms group had an elevated alanine aminotransferase (ALT) [pooled mean difference (MD), 4.5 U/L; 95% confidence interval, [0.45, 8.55]; p = 0.03; I(2) = 87%]. No publication bias was detected by Begg’s and Egger’s regression test (p = 0.130). COVID-19 with the GI symptoms also showed a trend toward decreased white blood cell count, lymphopenia, neutrophilia, thrombocytopenia and elevated total bilirubin. CONCLUSION: GI symptoms are common in COVID-19. No significant differences were found in most laboratory indicators except elevated ALT. REGISTRATION: CRD42020209039 (PROSPERO).
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spelling pubmed-94034432022-08-26 Comparison of laboratory characteristics of gastrointestinal symptoms and nongastrointestinal symptoms in patients infected with COVID-19: a systematic review and meta-analysis Zhao, Rui Shi, Jie Song, Yichuan Zhang, Rui Therap Adv Gastroenterol Meta-Analysis BACKGROUND: The Coronavirus Disease 2019 (COVID-19) pandemic poses a massive crisis to global public health. Gastrointestinal (GI) symptoms are increasingly reported in COVID-19. The characteristics of laboratory findings of COVID-19 are critical for clinical diagnosis and treatment. OBJECTIVES: The study aimed to summarize laboratory features in COVID-19 with GI symptoms and non-GI symptoms. DESIGN: This study was a systematic review and meta-analysis. Electronic literature searches were conducted for studies that included patients infected COVID-19 with GI symptoms and non-GI symptoms. GI symptoms included diarrhea, abdominal pain, nausea and vomiting, and anorexia. This study used a random-effects model to assess pooled data. DATA SOURCES AND METHODS: We systematically searched PubMed, Embase, Cochrane, Web of Science for studies through 31 October 2021, with no language restrictions. We used the following search terms: ‘COVID-19’ OR ‘2019-nCoV’ OR ‘SARS-CoV-2’ OR ‘coronavirus 2019’ OR ‘severe acute respiratory syndrome coronavirus 2’ OR ‘coronavirus’ OR ‘novel coronavirus’ OR ‘nCoV’ AND ‘gastrointestinal symptoms’ OR ‘digestive symptoms’ AND ‘clinical feature’ OR ‘clinical characteristics.’ Data mostly originated from Chinese and American studies. RESULTS: Of 796 identified studies, 14 were eligible and were included in our analysis (N = 8396 participants). Meta-analysis showed that GI symptoms group had an elevated alanine aminotransferase (ALT) [pooled mean difference (MD), 4.5 U/L; 95% confidence interval, [0.45, 8.55]; p = 0.03; I(2) = 87%]. No publication bias was detected by Begg’s and Egger’s regression test (p = 0.130). COVID-19 with the GI symptoms also showed a trend toward decreased white blood cell count, lymphopenia, neutrophilia, thrombocytopenia and elevated total bilirubin. CONCLUSION: GI symptoms are common in COVID-19. No significant differences were found in most laboratory indicators except elevated ALT. REGISTRATION: CRD42020209039 (PROSPERO). SAGE Publications 2022-08-22 /pmc/articles/PMC9403443/ /pubmed/36035309 http://dx.doi.org/10.1177/17562848221116264 Text en © The Author(s), 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Meta-Analysis
Zhao, Rui
Shi, Jie
Song, Yichuan
Zhang, Rui
Comparison of laboratory characteristics of gastrointestinal symptoms and nongastrointestinal symptoms in patients infected with COVID-19: a systematic review and meta-analysis
title Comparison of laboratory characteristics of gastrointestinal symptoms and nongastrointestinal symptoms in patients infected with COVID-19: a systematic review and meta-analysis
title_full Comparison of laboratory characteristics of gastrointestinal symptoms and nongastrointestinal symptoms in patients infected with COVID-19: a systematic review and meta-analysis
title_fullStr Comparison of laboratory characteristics of gastrointestinal symptoms and nongastrointestinal symptoms in patients infected with COVID-19: a systematic review and meta-analysis
title_full_unstemmed Comparison of laboratory characteristics of gastrointestinal symptoms and nongastrointestinal symptoms in patients infected with COVID-19: a systematic review and meta-analysis
title_short Comparison of laboratory characteristics of gastrointestinal symptoms and nongastrointestinal symptoms in patients infected with COVID-19: a systematic review and meta-analysis
title_sort comparison of laboratory characteristics of gastrointestinal symptoms and nongastrointestinal symptoms in patients infected with covid-19: a systematic review and meta-analysis
topic Meta-Analysis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9403443/
https://www.ncbi.nlm.nih.gov/pubmed/36035309
http://dx.doi.org/10.1177/17562848221116264
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