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Drug-related problems and associated factors among adult psychiatric inpatients in Northwest Ethiopia: Multicenter cross-sectional study

OBJECTIVE: To determine the prevalence of drug-related problems and the factors influencing them among adult psychiatric inpatients. METHODS: A multi-centre cross-sectional observational study was conducted from April to July 2021 at five randomly selected hospitals in Northwest Ethiopia. A total of...

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Autores principales: Dagnew, Ephrem Mebratu, Ayalew, Mohammed Biset, Alemnew Mekonnen, Gizework, Geremew, Alehegn Bishaw, Abdela, Ousman Abubeker
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9403454/
https://www.ncbi.nlm.nih.gov/pubmed/36032653
http://dx.doi.org/10.1177/20503121221112485
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author Dagnew, Ephrem Mebratu
Ayalew, Mohammed Biset
Alemnew Mekonnen, Gizework
Geremew, Alehegn Bishaw
Abdela, Ousman Abubeker
author_facet Dagnew, Ephrem Mebratu
Ayalew, Mohammed Biset
Alemnew Mekonnen, Gizework
Geremew, Alehegn Bishaw
Abdela, Ousman Abubeker
author_sort Dagnew, Ephrem Mebratu
collection PubMed
description OBJECTIVE: To determine the prevalence of drug-related problems and the factors influencing them among adult psychiatric inpatients. METHODS: A multi-centre cross-sectional observational study was conducted from April to July 2021 at five randomly selected hospitals in Northwest Ethiopia. A total of 325 consecutively sampled patients participated in the study. Clinical pharmacists assessed the drug-related problems based on clinical judgement supported by updated evidence-based disease guidelines. We used the Medscape drug-interactions checker to check drug-to-drug interactions. The results were summarised using descriptive statistics, including frequency, mean, and standard deviation. For each variable, an odds ratio with a 95% confidence interval was calculated, as well as the related p-value. The value of p ⩽ 0.05 was considered statistically significant. RESULTS: From the total number of 325 study participants, more than half of them (52.9%) were females, and the mean age ± (standard deviation) was 30.8 ± 11.3 years. At least one drug-related problem was recorded by 60.9% to 95% confidence interval (55.7–65.8) of study participants, with a mean of 0.6 ± 0.49 per patient. Additional drug therapy was the most common drug-related problem (22.8%) followed by non-adherence to medicine (20.6%) and adverse drug reactions (11%), respectively. Factors independent associated with drug-related problems were rural residence (adjusted odds ratio = 1.96, 95% confidence interval: 1.01–2.84, p-value = 0.046), self-employed (adjusted odds ratio = 6.0, 95% confidence interval: 1.0–36.9, p-value = 0.035) and alcohol drinkers (adjusted odds ratio = 6.40, 95% confidence interval: 1.12–37.5, p-value = 0.034). CONCLUSION: The prevalence of drug-related problems among adult psychiatric patients admitted to psychiatric wards was high. Healthcare providers give more attention to tackling these problems. Being a rural resident, self-employed, and alcohol drinkers were associated with drug-related problems.
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spelling pubmed-94034542022-08-26 Drug-related problems and associated factors among adult psychiatric inpatients in Northwest Ethiopia: Multicenter cross-sectional study Dagnew, Ephrem Mebratu Ayalew, Mohammed Biset Alemnew Mekonnen, Gizework Geremew, Alehegn Bishaw Abdela, Ousman Abubeker SAGE Open Med Original Research Article OBJECTIVE: To determine the prevalence of drug-related problems and the factors influencing them among adult psychiatric inpatients. METHODS: A multi-centre cross-sectional observational study was conducted from April to July 2021 at five randomly selected hospitals in Northwest Ethiopia. A total of 325 consecutively sampled patients participated in the study. Clinical pharmacists assessed the drug-related problems based on clinical judgement supported by updated evidence-based disease guidelines. We used the Medscape drug-interactions checker to check drug-to-drug interactions. The results were summarised using descriptive statistics, including frequency, mean, and standard deviation. For each variable, an odds ratio with a 95% confidence interval was calculated, as well as the related p-value. The value of p ⩽ 0.05 was considered statistically significant. RESULTS: From the total number of 325 study participants, more than half of them (52.9%) were females, and the mean age ± (standard deviation) was 30.8 ± 11.3 years. At least one drug-related problem was recorded by 60.9% to 95% confidence interval (55.7–65.8) of study participants, with a mean of 0.6 ± 0.49 per patient. Additional drug therapy was the most common drug-related problem (22.8%) followed by non-adherence to medicine (20.6%) and adverse drug reactions (11%), respectively. Factors independent associated with drug-related problems were rural residence (adjusted odds ratio = 1.96, 95% confidence interval: 1.01–2.84, p-value = 0.046), self-employed (adjusted odds ratio = 6.0, 95% confidence interval: 1.0–36.9, p-value = 0.035) and alcohol drinkers (adjusted odds ratio = 6.40, 95% confidence interval: 1.12–37.5, p-value = 0.034). CONCLUSION: The prevalence of drug-related problems among adult psychiatric patients admitted to psychiatric wards was high. Healthcare providers give more attention to tackling these problems. Being a rural resident, self-employed, and alcohol drinkers were associated with drug-related problems. SAGE Publications 2022-08-22 /pmc/articles/PMC9403454/ /pubmed/36032653 http://dx.doi.org/10.1177/20503121221112485 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Research Article
Dagnew, Ephrem Mebratu
Ayalew, Mohammed Biset
Alemnew Mekonnen, Gizework
Geremew, Alehegn Bishaw
Abdela, Ousman Abubeker
Drug-related problems and associated factors among adult psychiatric inpatients in Northwest Ethiopia: Multicenter cross-sectional study
title Drug-related problems and associated factors among adult psychiatric inpatients in Northwest Ethiopia: Multicenter cross-sectional study
title_full Drug-related problems and associated factors among adult psychiatric inpatients in Northwest Ethiopia: Multicenter cross-sectional study
title_fullStr Drug-related problems and associated factors among adult psychiatric inpatients in Northwest Ethiopia: Multicenter cross-sectional study
title_full_unstemmed Drug-related problems and associated factors among adult psychiatric inpatients in Northwest Ethiopia: Multicenter cross-sectional study
title_short Drug-related problems and associated factors among adult psychiatric inpatients in Northwest Ethiopia: Multicenter cross-sectional study
title_sort drug-related problems and associated factors among adult psychiatric inpatients in northwest ethiopia: multicenter cross-sectional study
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9403454/
https://www.ncbi.nlm.nih.gov/pubmed/36032653
http://dx.doi.org/10.1177/20503121221112485
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