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Landscape of the epigenetic regulation in wound healing
Wound healing after skin injury is a dynamic and highly coordinated process involving a well-orchestrated series of phases, including hemostasis, inflammation, proliferation, and tissue remodeling. Epigenetic regulation refers to genome-wide molecular events, including DNA methylation, histone modif...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9403478/ https://www.ncbi.nlm.nih.gov/pubmed/36035490 http://dx.doi.org/10.3389/fphys.2022.949498 |
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author | Yu, Honghao Wang, Yichen Wang, Dawei Yi, Yi Liu, Zeming Wu, Min Wu, Yiping Zhang, Qi |
author_facet | Yu, Honghao Wang, Yichen Wang, Dawei Yi, Yi Liu, Zeming Wu, Min Wu, Yiping Zhang, Qi |
author_sort | Yu, Honghao |
collection | PubMed |
description | Wound healing after skin injury is a dynamic and highly coordinated process involving a well-orchestrated series of phases, including hemostasis, inflammation, proliferation, and tissue remodeling. Epigenetic regulation refers to genome-wide molecular events, including DNA methylation, histone modification, and non-coding RNA regulation, represented by microRNA (miRNA), long noncoding RNA (lncRNA), and circular RNA (circRNA). Epigenetic regulation is pervasively occurred in the genome and emerges as a new role in gene expression at the post-transcriptional level. Currently, it is well-recognized that epigenetic factors are determinants in regulating gene expression patterns, and may provide evolutionary mechanisms that influence the wound microenvironments and the entire healing course. Therefore, this review aims to comprehensively summarize the emerging roles and mechanisms of epigenetic remodeling in wound healing. Moreover, we also pose the challenges and future perspectives related to epigenetic modifications in wound healing, which would bring novel insights to accelerated wound healing. |
format | Online Article Text |
id | pubmed-9403478 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94034782022-08-26 Landscape of the epigenetic regulation in wound healing Yu, Honghao Wang, Yichen Wang, Dawei Yi, Yi Liu, Zeming Wu, Min Wu, Yiping Zhang, Qi Front Physiol Physiology Wound healing after skin injury is a dynamic and highly coordinated process involving a well-orchestrated series of phases, including hemostasis, inflammation, proliferation, and tissue remodeling. Epigenetic regulation refers to genome-wide molecular events, including DNA methylation, histone modification, and non-coding RNA regulation, represented by microRNA (miRNA), long noncoding RNA (lncRNA), and circular RNA (circRNA). Epigenetic regulation is pervasively occurred in the genome and emerges as a new role in gene expression at the post-transcriptional level. Currently, it is well-recognized that epigenetic factors are determinants in regulating gene expression patterns, and may provide evolutionary mechanisms that influence the wound microenvironments and the entire healing course. Therefore, this review aims to comprehensively summarize the emerging roles and mechanisms of epigenetic remodeling in wound healing. Moreover, we also pose the challenges and future perspectives related to epigenetic modifications in wound healing, which would bring novel insights to accelerated wound healing. Frontiers Media S.A. 2022-08-11 /pmc/articles/PMC9403478/ /pubmed/36035490 http://dx.doi.org/10.3389/fphys.2022.949498 Text en Copyright © 2022 Yu, Wang, Wang, Yi, Liu, Wu, Wu and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Yu, Honghao Wang, Yichen Wang, Dawei Yi, Yi Liu, Zeming Wu, Min Wu, Yiping Zhang, Qi Landscape of the epigenetic regulation in wound healing |
title | Landscape of the epigenetic regulation in wound healing |
title_full | Landscape of the epigenetic regulation in wound healing |
title_fullStr | Landscape of the epigenetic regulation in wound healing |
title_full_unstemmed | Landscape of the epigenetic regulation in wound healing |
title_short | Landscape of the epigenetic regulation in wound healing |
title_sort | landscape of the epigenetic regulation in wound healing |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9403478/ https://www.ncbi.nlm.nih.gov/pubmed/36035490 http://dx.doi.org/10.3389/fphys.2022.949498 |
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