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Urinary biomarkers for the early prediction of bronchopulmonary dysplasia in preterm infants: A pilot study
BACKGROUND: This study investigated whether 8-hydroxy-2’-deoxyguanosine (8-OHdG) and N-terminal pro-brain natriuretic peptide (NT-proBNP) concentrations in the urine could predict bronchopulmonary dysplasia (BPD) in preterm infants. METHODS: This prospective cohort study enrolled 165 preterm infants...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9403535/ https://www.ncbi.nlm.nih.gov/pubmed/36034571 http://dx.doi.org/10.3389/fped.2022.959513 |
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author | Cui, Xuewei Fu, Jianhua |
author_facet | Cui, Xuewei Fu, Jianhua |
author_sort | Cui, Xuewei |
collection | PubMed |
description | BACKGROUND: This study investigated whether 8-hydroxy-2’-deoxyguanosine (8-OHdG) and N-terminal pro-brain natriuretic peptide (NT-proBNP) concentrations in the urine could predict bronchopulmonary dysplasia (BPD) in preterm infants. METHODS: This prospective cohort study enrolled 165 preterm infants, of whom 70 developed BPD. We measured urinary 8-OHdG and NT-proBNP concentrations from day of life (DOL) 7 to 28. Then, we evaluated the prediction efficiency by receiver operating characteristic curves and assessed correlations between the two biomarkers. Finally, we identified the predictive risk factors for BPD by multivariable logistic regression. RESULTS: 8-OHdG and NT-proBNP levels were significantly higher from DOL 7 to 28 in the BPD group than in the control group (P < 0.05). Additionally, the 8-OHdG level was positively correlated with the NT-proBNP level (r: 0.655–0.789, P < 0.001), and the 8-OHdG and NT-proBNP levels were positively correlated with mechanical ventilation duration and oxygen exposure time (r: 0.175–0.505, P < 0.05) from DOL 7 to 28. Furthermore, the 8-OHdG (DOL 14–28) and NT-proBNP (DOL 7–28) levels were significantly associated with BPD development (P < 0.05). CONCLUSION: The urine 8-OHdG concentrations from DOL 14 to 28 and NT-proBNP concentrations from DOL 7 to 28 may be practical non-invasive predictors of BPD development in preterm infants. |
format | Online Article Text |
id | pubmed-9403535 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94035352022-08-26 Urinary biomarkers for the early prediction of bronchopulmonary dysplasia in preterm infants: A pilot study Cui, Xuewei Fu, Jianhua Front Pediatr Pediatrics BACKGROUND: This study investigated whether 8-hydroxy-2’-deoxyguanosine (8-OHdG) and N-terminal pro-brain natriuretic peptide (NT-proBNP) concentrations in the urine could predict bronchopulmonary dysplasia (BPD) in preterm infants. METHODS: This prospective cohort study enrolled 165 preterm infants, of whom 70 developed BPD. We measured urinary 8-OHdG and NT-proBNP concentrations from day of life (DOL) 7 to 28. Then, we evaluated the prediction efficiency by receiver operating characteristic curves and assessed correlations between the two biomarkers. Finally, we identified the predictive risk factors for BPD by multivariable logistic regression. RESULTS: 8-OHdG and NT-proBNP levels were significantly higher from DOL 7 to 28 in the BPD group than in the control group (P < 0.05). Additionally, the 8-OHdG level was positively correlated with the NT-proBNP level (r: 0.655–0.789, P < 0.001), and the 8-OHdG and NT-proBNP levels were positively correlated with mechanical ventilation duration and oxygen exposure time (r: 0.175–0.505, P < 0.05) from DOL 7 to 28. Furthermore, the 8-OHdG (DOL 14–28) and NT-proBNP (DOL 7–28) levels were significantly associated with BPD development (P < 0.05). CONCLUSION: The urine 8-OHdG concentrations from DOL 14 to 28 and NT-proBNP concentrations from DOL 7 to 28 may be practical non-invasive predictors of BPD development in preterm infants. Frontiers Media S.A. 2022-08-11 /pmc/articles/PMC9403535/ /pubmed/36034571 http://dx.doi.org/10.3389/fped.2022.959513 Text en Copyright © 2022 Cui and Fu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pediatrics Cui, Xuewei Fu, Jianhua Urinary biomarkers for the early prediction of bronchopulmonary dysplasia in preterm infants: A pilot study |
title | Urinary biomarkers for the early prediction of bronchopulmonary dysplasia in preterm infants: A pilot study |
title_full | Urinary biomarkers for the early prediction of bronchopulmonary dysplasia in preterm infants: A pilot study |
title_fullStr | Urinary biomarkers for the early prediction of bronchopulmonary dysplasia in preterm infants: A pilot study |
title_full_unstemmed | Urinary biomarkers for the early prediction of bronchopulmonary dysplasia in preterm infants: A pilot study |
title_short | Urinary biomarkers for the early prediction of bronchopulmonary dysplasia in preterm infants: A pilot study |
title_sort | urinary biomarkers for the early prediction of bronchopulmonary dysplasia in preterm infants: a pilot study |
topic | Pediatrics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9403535/ https://www.ncbi.nlm.nih.gov/pubmed/36034571 http://dx.doi.org/10.3389/fped.2022.959513 |
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