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Urinary biomarkers for the early prediction of bronchopulmonary dysplasia in preterm infants: A pilot study

BACKGROUND: This study investigated whether 8-hydroxy-2’-deoxyguanosine (8-OHdG) and N-terminal pro-brain natriuretic peptide (NT-proBNP) concentrations in the urine could predict bronchopulmonary dysplasia (BPD) in preterm infants. METHODS: This prospective cohort study enrolled 165 preterm infants...

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Autores principales: Cui, Xuewei, Fu, Jianhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9403535/
https://www.ncbi.nlm.nih.gov/pubmed/36034571
http://dx.doi.org/10.3389/fped.2022.959513
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author Cui, Xuewei
Fu, Jianhua
author_facet Cui, Xuewei
Fu, Jianhua
author_sort Cui, Xuewei
collection PubMed
description BACKGROUND: This study investigated whether 8-hydroxy-2’-deoxyguanosine (8-OHdG) and N-terminal pro-brain natriuretic peptide (NT-proBNP) concentrations in the urine could predict bronchopulmonary dysplasia (BPD) in preterm infants. METHODS: This prospective cohort study enrolled 165 preterm infants, of whom 70 developed BPD. We measured urinary 8-OHdG and NT-proBNP concentrations from day of life (DOL) 7 to 28. Then, we evaluated the prediction efficiency by receiver operating characteristic curves and assessed correlations between the two biomarkers. Finally, we identified the predictive risk factors for BPD by multivariable logistic regression. RESULTS: 8-OHdG and NT-proBNP levels were significantly higher from DOL 7 to 28 in the BPD group than in the control group (P < 0.05). Additionally, the 8-OHdG level was positively correlated with the NT-proBNP level (r: 0.655–0.789, P < 0.001), and the 8-OHdG and NT-proBNP levels were positively correlated with mechanical ventilation duration and oxygen exposure time (r: 0.175–0.505, P < 0.05) from DOL 7 to 28. Furthermore, the 8-OHdG (DOL 14–28) and NT-proBNP (DOL 7–28) levels were significantly associated with BPD development (P < 0.05). CONCLUSION: The urine 8-OHdG concentrations from DOL 14 to 28 and NT-proBNP concentrations from DOL 7 to 28 may be practical non-invasive predictors of BPD development in preterm infants.
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spelling pubmed-94035352022-08-26 Urinary biomarkers for the early prediction of bronchopulmonary dysplasia in preterm infants: A pilot study Cui, Xuewei Fu, Jianhua Front Pediatr Pediatrics BACKGROUND: This study investigated whether 8-hydroxy-2’-deoxyguanosine (8-OHdG) and N-terminal pro-brain natriuretic peptide (NT-proBNP) concentrations in the urine could predict bronchopulmonary dysplasia (BPD) in preterm infants. METHODS: This prospective cohort study enrolled 165 preterm infants, of whom 70 developed BPD. We measured urinary 8-OHdG and NT-proBNP concentrations from day of life (DOL) 7 to 28. Then, we evaluated the prediction efficiency by receiver operating characteristic curves and assessed correlations between the two biomarkers. Finally, we identified the predictive risk factors for BPD by multivariable logistic regression. RESULTS: 8-OHdG and NT-proBNP levels were significantly higher from DOL 7 to 28 in the BPD group than in the control group (P < 0.05). Additionally, the 8-OHdG level was positively correlated with the NT-proBNP level (r: 0.655–0.789, P < 0.001), and the 8-OHdG and NT-proBNP levels were positively correlated with mechanical ventilation duration and oxygen exposure time (r: 0.175–0.505, P < 0.05) from DOL 7 to 28. Furthermore, the 8-OHdG (DOL 14–28) and NT-proBNP (DOL 7–28) levels were significantly associated with BPD development (P < 0.05). CONCLUSION: The urine 8-OHdG concentrations from DOL 14 to 28 and NT-proBNP concentrations from DOL 7 to 28 may be practical non-invasive predictors of BPD development in preterm infants. Frontiers Media S.A. 2022-08-11 /pmc/articles/PMC9403535/ /pubmed/36034571 http://dx.doi.org/10.3389/fped.2022.959513 Text en Copyright © 2022 Cui and Fu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Cui, Xuewei
Fu, Jianhua
Urinary biomarkers for the early prediction of bronchopulmonary dysplasia in preterm infants: A pilot study
title Urinary biomarkers for the early prediction of bronchopulmonary dysplasia in preterm infants: A pilot study
title_full Urinary biomarkers for the early prediction of bronchopulmonary dysplasia in preterm infants: A pilot study
title_fullStr Urinary biomarkers for the early prediction of bronchopulmonary dysplasia in preterm infants: A pilot study
title_full_unstemmed Urinary biomarkers for the early prediction of bronchopulmonary dysplasia in preterm infants: A pilot study
title_short Urinary biomarkers for the early prediction of bronchopulmonary dysplasia in preterm infants: A pilot study
title_sort urinary biomarkers for the early prediction of bronchopulmonary dysplasia in preterm infants: a pilot study
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9403535/
https://www.ncbi.nlm.nih.gov/pubmed/36034571
http://dx.doi.org/10.3389/fped.2022.959513
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