Pharmacological FGF21 signals to glutamatergic neurons to enhance leptin action and lower body weight during obesity

OBJECTIVE: Fibroblast growth factor 21 (FGF21) is a peripherally-derived endocrine hormone that acts on the central nervous system (CNS) to regulate whole body energy homeostasis. Pharmacological administration of FGF21 promotes weight loss in obese animal models and human subjects with obesity. How...

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Detalles Bibliográficos
Autores principales: Claflin, Kristin E., Sullivan, Andrew I., Naber, Meghan C., Flippo, Kyle H., Morgan, Donald A., Neff, Tate J., Jensen-Cody, Sharon O., Zhu, Zhiyong, Zingman, Leonid V., Rahmouni, Kamal, Potthoff, Matthew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9403559/
https://www.ncbi.nlm.nih.gov/pubmed/35944896
http://dx.doi.org/10.1016/j.molmet.2022.101564

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