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Phosphoglyceride crystal deposition disease requiring differential diagnosis from malignant tumors and confirmed by Raman spectroscopy: A case report
BACKGROUND: Phosphoglyceride crystal deposition disease (PCDD) is a rare acquired disease in which phospholipid crystals deposit in bone and soft tissue long after surgery, trauma, or repeated injections. CASE SUMMARY: A 60-year-old-woman was referred to our department because of multiple abdominal...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Baishideng Publishing Group Inc
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9403676/ https://www.ncbi.nlm.nih.gov/pubmed/36159533 http://dx.doi.org/10.12998/wjcc.v10.i23.8304 |
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author | Ohkura, Yu Uruga, Hironori Shiiba, Masato Ito, Shinji Shimoyama, Hayato Ishihara, Makiko Ueno, Masaki Udagawa, Harushi |
author_facet | Ohkura, Yu Uruga, Hironori Shiiba, Masato Ito, Shinji Shimoyama, Hayato Ishihara, Makiko Ueno, Masaki Udagawa, Harushi |
author_sort | Ohkura, Yu |
collection | PubMed |
description | BACKGROUND: Phosphoglyceride crystal deposition disease (PCDD) is a rare acquired disease in which phospholipid crystals deposit in bone and soft tissue long after surgery, trauma, or repeated injections. CASE SUMMARY: A 60-year-old-woman was referred to our department because of multiple abdominal masses after open splenectomy for idiopathic thrombocytopenic purpura 29 years earlier. All the masses showed marked fluorodeoxyglucose (FDG) uptake on (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG-PET) and were strongly suspected to be malignant tumors. Surgical biopsies were performed, and the abdominal masses were found to be aligned vertically, three in a row, along the tissue layers cut in the patient’s previous surgery. Pathological finding of the specimens showed foreign body granuloma consisting of histiocytes and multinucleated giant cells accumulating around needle-like crystals. The crystals were confirmed as phosphoglyceride by Raman spectroscopy, and PCDD was diagnosed. To our knowledge, this is the first report of PCDD diagnosed by Raman spectroscopy. CONCLUSION: We made a definitive diagnosis of PCDD in a patient with multiple tumors showing marked FDG uptake on (18)F-FDG-PET by incisional biopsy and compo- sition analysis using Raman spectroscopy, a method that has not previously been reported for the diagnosis of PCDD. |
format | Online Article Text |
id | pubmed-9403676 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-94036762022-09-23 Phosphoglyceride crystal deposition disease requiring differential diagnosis from malignant tumors and confirmed by Raman spectroscopy: A case report Ohkura, Yu Uruga, Hironori Shiiba, Masato Ito, Shinji Shimoyama, Hayato Ishihara, Makiko Ueno, Masaki Udagawa, Harushi World J Clin Cases Case Report BACKGROUND: Phosphoglyceride crystal deposition disease (PCDD) is a rare acquired disease in which phospholipid crystals deposit in bone and soft tissue long after surgery, trauma, or repeated injections. CASE SUMMARY: A 60-year-old-woman was referred to our department because of multiple abdominal masses after open splenectomy for idiopathic thrombocytopenic purpura 29 years earlier. All the masses showed marked fluorodeoxyglucose (FDG) uptake on (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG-PET) and were strongly suspected to be malignant tumors. Surgical biopsies were performed, and the abdominal masses were found to be aligned vertically, three in a row, along the tissue layers cut in the patient’s previous surgery. Pathological finding of the specimens showed foreign body granuloma consisting of histiocytes and multinucleated giant cells accumulating around needle-like crystals. The crystals were confirmed as phosphoglyceride by Raman spectroscopy, and PCDD was diagnosed. To our knowledge, this is the first report of PCDD diagnosed by Raman spectroscopy. CONCLUSION: We made a definitive diagnosis of PCDD in a patient with multiple tumors showing marked FDG uptake on (18)F-FDG-PET by incisional biopsy and compo- sition analysis using Raman spectroscopy, a method that has not previously been reported for the diagnosis of PCDD. Baishideng Publishing Group Inc 2022-08-16 2022-08-16 /pmc/articles/PMC9403676/ /pubmed/36159533 http://dx.doi.org/10.12998/wjcc.v10.i23.8304 Text en ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
spellingShingle | Case Report Ohkura, Yu Uruga, Hironori Shiiba, Masato Ito, Shinji Shimoyama, Hayato Ishihara, Makiko Ueno, Masaki Udagawa, Harushi Phosphoglyceride crystal deposition disease requiring differential diagnosis from malignant tumors and confirmed by Raman spectroscopy: A case report |
title | Phosphoglyceride crystal deposition disease requiring differential diagnosis from malignant tumors and confirmed by Raman spectroscopy: A case report |
title_full | Phosphoglyceride crystal deposition disease requiring differential diagnosis from malignant tumors and confirmed by Raman spectroscopy: A case report |
title_fullStr | Phosphoglyceride crystal deposition disease requiring differential diagnosis from malignant tumors and confirmed by Raman spectroscopy: A case report |
title_full_unstemmed | Phosphoglyceride crystal deposition disease requiring differential diagnosis from malignant tumors and confirmed by Raman spectroscopy: A case report |
title_short | Phosphoglyceride crystal deposition disease requiring differential diagnosis from malignant tumors and confirmed by Raman spectroscopy: A case report |
title_sort | phosphoglyceride crystal deposition disease requiring differential diagnosis from malignant tumors and confirmed by raman spectroscopy: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9403676/ https://www.ncbi.nlm.nih.gov/pubmed/36159533 http://dx.doi.org/10.12998/wjcc.v10.i23.8304 |
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