Cargando…

Application of Artificial Intelligence to Plasma Metabolomics Profiles to Predict Response to Neoadjuvant Chemotherapy in Triple-Negative Breast Cancer

There is a need to identify biomarkers predictive of response to neoadjuvant chemotherapy (NACT) in triple-negative breast cancer (TNBC). We previously obtained evidence that a polyamine signature in the blood is associated with TNBC development and progression. In this study, we evaluated whether p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Irajizad, Ehsan, Wu, Ranran, Vykoukal, Jody, Murage, Eunice, Spencer, Rachelle, Dennison, Jennifer B., Moulder, Stacy, Ravenberg, Elizabeth, Lim, Bora, Litton, Jennifer, Tripathym, Debu, Valero, Vicente, Damodaran, Senthil, Rauch, Gaiane M., Adrada, Beatriz, Candelaria, Rosalind, White, Jason B., Brewster, Abenaa, Arun, Banu, Long, James P., Do, Kim Anh, Hanash, Sam, Fahrmann, Johannes F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Artificial Intelligence
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9403735/ https://www.ncbi.nlm.nih.gov/pubmed/36034598 http://dx.doi.org/10.3389/frai.2022.876100

Ejemplares similares

A MYC-Driven Plasma Polyamine Signature for Early Detection of Ovarian Cancer
por: Fahrmann, Johannes F., et al.
Publicado: (2021)

Kynureninase Upregulation Is a Prominent Feature of NFR2-Activated Cancers and Is Associated with Tumor Immunosuppression and Poor Prognosis
por: León-Letelier, Ricardo A., et al.
Publicado: (2023)

Prognostic Impact of High Baseline Stromal Tumor-Infiltrating Lymphocytes in the Absence of Pathologic Complete Response in Early-Stage Triple-Negative Breast Cancer
por: Abuhadra, Nour, et al.
Publicado: (2022)

Predictive Roles of Baseline Stromal Tumor-Infiltrating Lymphocytes and Ki-67 in Pathologic Complete Response in an Early-Stage Triple-Negative Breast Cancer Prospective Trial
por: Abuhadra, Nour, et al.
Publicado: (2023)

Plasma Based Protein Signatures Associated with Small Cell Lung Cancer
por: Fahrmann, Johannes F., et al.
Publicado: (2021)

c-MYC-Driven Polyamine Metabolism in Ovarian Cancer: From Pathogenesis to Early Detection and Therapy
por: Chen, Yihui, et al.
Publicado: (2023)

Caveolin-1-mediated sphingolipid oncometabolism underlies a metabolic vulnerability of prostate cancer
por: Vykoukal, Jody, et al.
Publicado: (2020)

Extracellular Vesicles Mediate B Cell Immune Response and Are a Potential Target for Cancer Therapy
por: Kato, Taketo, et al.
Publicado: (2020)

Extracellular Vesicles in Lung Cancer: Prospects for Diagnostic and Therapeutic Applications
por: Kato, Taketo, et al.
Publicado: (2021)

Novel UHRF1-MYC Axis in Acute Lymphoblastic Leukemia
por: Park, Soyoung, et al.
Publicado: (2022)

PTEN in triple-negative breast carcinoma: protein expression and genomic alteration in pretreatment and posttreatment specimens
por: Chen, Hui, et al.
Publicado: (2023)

Mutational Activation of the NRF2 Pathway Upregulates Kynureninase Resulting in Tumor Immunosuppression and Poor Outcome in Lung Adenocarcinoma
por: Fahrmann, Johannes F., et al.
Publicado: (2022)

A blood-based metabolomic signature predictive of risk for pancreatic cancer
por: Irajizad, Ehsan, et al.
Publicado: (2023)

Plasma-Derived Extracellular Vesicles Convey Protein Signatures That Reflect Pathophysiology in Lung and Pancreatic Adenocarcinomas
por: Fahrmann, Johannes F., et al.
Publicado: (2020)

Imaging of Noncalcified Ductal Carcinoma In Situ
por: Bragg, Ashley, et al.
Publicado: (2021)

The kynurenine pathway presents multi-faceted metabolic vulnerabilities in cancer
por: León-Letelier, Ricardo A., et al.
Publicado: (2023)

Protein citrullination as a source of cancer neoantigens
por: Katayama, Hiroyuki, et al.
Publicado: (2021)

A Plasma-Derived Protein-Metabolite Multiplexed Panel for Early-Stage Pancreatic Cancer
por: Fahrmann, Johannes F, et al.
Publicado: (2018)

Amino Acid Oncometabolism and Immunomodulation of the Tumor Microenvironment in Lung Cancer
por: Fahrmann, Johannes F., et al.
Publicado: (2020)

Contributions of Circulating microRNAs for Early Detection of Lung Cancer
por: Vykoukal, Jody, et al.
Publicado: (2022)

A Comprehensive Search of Non-Canonical Proteins in Non-Small Cell Lung Cancer and Their Impact on the Immune Response
por: Irajizad, Ehsan, et al.
Publicado: (2022)

CES2 sustains HNF4α expression to promote pancreatic adenocarcinoma progression through an epoxide hydrolase-dependent regulatory loop
por: Chen, Yihui, et al.
Publicado: (2021)

Mimickers of breast malignancy: imaging findings, pathologic concordance and clinical management
por: Guirguis, Mary S., et al.
Publicado: (2021)

A polyamine-centric, blood-based metabolite panel predictive of poor response to CAR-T cell therapy in large B cell lymphoma
por: Fahrmann, Johannes F., et al.
Publicado: (2022)

Predictors of success in establishing orthotopic patient-derived xenograft models of triple negative breast cancer
por: Echeverria, Gloria V., et al.
Publicado: (2023)

Plasma-derived extracellular vesicle proteins as a source of biomarkers for lung adenocarcinoma
por: Vykoukal, Jody, et al.
Publicado: (2017)

Proteome Profiling Uncovers an Autoimmune Response Signature That Reflects Ovarian Cancer Pathogenesis
por: Kobayashi, Makoto, et al.
Publicado: (2020)

Imaging Surveillance of the Reconstructed Breast in a Subset of Patients May Aid in Early Detection of Breast Cancer Recurrence
por: Adrada, Beatriz Elena, et al.
Publicado: (2021)

Prediction of pathologic complete response to neoadjuvant systemic therapy in triple negative breast cancer using deep learning on multiparametric MRI
por: Zhou, Zijian, et al.
Publicado: (2023)

Longitudinal dynamic contrast-enhanced MRI radiomic models for early prediction of response to neoadjuvant systemic therapy in triple-negative breast cancer
por: Panthi, Bikash, et al.
Publicado: (2023)

Exercise Training Reduces the Inflammatory Response and Promotes Intestinal Mucosa-Associated Immunity in Lynch Syndrome
por: Deng, Nan, et al.
Publicado: (2023)

Influencers of the Decision to Undergo Contralateral Prophylactic Mastectomy among Women with Unilateral Breast Cancer
por: Singareeka Raghavendra, Akshara, et al.
Publicado: (2021)

Assessment of Response to Neoadjuvant Systemic Treatment in Triple-Negative Breast Cancer Using Functional Tumor Volumes from Longitudinal Dynamic Contrast-Enhanced MRI
por: Panthi, Bikash, et al.
Publicado: (2023)

Better contralateral breast cancer risk estimation and alternative options to contralateral prophylactic mastectomy
por: Davies, Kalatu R, et al.
Publicado: (2015)

Improved Method for Isolation of Neonatal Rat Cardiomyocytes with Increased Yield of C-Kit+ Cardiac Progenitor Cells
por: Rutering, Jennifer, et al.
Publicado: (2015)

Association of Body Mass Index Changes during Neoadjuvant Chemotherapy with Pathologic Complete Response and Clinical Outcomes in Patients with Locally Advanced Breast Cancer
por: Kogawa, Takahiro, et al.
Publicado: (2015)

Tumor-suppressor activity of RRIG1 in breast cancer
por: Zhang, Guihong, et al.
Publicado: (2011)

Deep Learning for Fully Automatic Tumor Segmentation on Serially Acquired Dynamic Contrast-Enhanced MRI Images of Triple-Negative Breast Cancer
por: Xu, Zhan, et al.
Publicado: (2023)

Differential Effects of Coating Materials on Viability and Migration of Schwann Cells
por: Klein, Silvan, et al.
Publicado: (2016)

Collagen Type I Conduits for the Regeneration of Nerve Defects
por: Klein, Silvan, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_ab9qjejr4dgq6dfh1lrc95j8su